ID   Y3032_BACAN             Reviewed;         584 AA.
AC   Q6HX62; Q6KR89; Q81NY9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Putative adenine deaminase BA_3032/GBAA_3032/BAS2818;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   OrderedLocusNames=BA_3032, GBAA_3032, BAS2818;
OS   Bacillus anthracis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames / isolate Porton;
RX   PubMed=12721629; DOI=10.1038/nature01586;
RA   Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA   Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA   Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA   Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA   DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA   Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA   Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA   Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA   White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA   Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT   "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT   related bacteria.";
RL   Nature 423:81-86(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sterne;
RA   Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA   Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA   Richardson P., Rubin E., Tice H.;
RT   "Complete genome sequence of Bacillus anthracis Sterne.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000305}.
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DR   EMBL; AE016879; AAP26849.1; -; Genomic_DNA.
DR   EMBL; AE017334; AAT32147.1; -; Genomic_DNA.
DR   EMBL; AE017225; AAT55127.1; -; Genomic_DNA.
DR   RefSeq; NP_845363.1; NC_003997.3.
DR   RefSeq; WP_000531401.1; NZ_WXXJ01000029.1.
DR   RefSeq; YP_029076.1; NC_005945.1.
DR   AlphaFoldDB; Q6HX62; -.
DR   SMR; Q6HX62; -.
DR   STRING; 260799.BAS2818; -.
DR   DNASU; 1088144; -.
DR   EnsemblBacteria; AAP26849; AAP26849; BA_3032.
DR   EnsemblBacteria; AAT32147; AAT32147; GBAA_3032.
DR   GeneID; 45022842; -.
DR   KEGG; ban:BA_3032; -.
DR   KEGG; bar:GBAA_3032; -.
DR   KEGG; bat:BAS2818; -.
DR   PATRIC; fig|198094.11.peg.3012; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; IEGHFPG; -.
DR   Proteomes; UP000000427; Chromosome.
DR   Proteomes; UP000000594; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.30.40.10; -; 1.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..584
FT                   /note="Putative adenine deaminase
FT                   BA_3032/GBAA_3032/BAS2818"
FT                   /id="PRO_0000142444"
SQ   SEQUENCE   584 AA;  66760 MW;  716FA8A75C14B3CF CRC64;
     MGQNQFRWSN EQLREHVEII DGTRSPHKLL KNATYLNSYI REWMQANIWI YDDRIIYVGE
     KLPEQLHECE VIDCDGKYVV PSYIEPHAHP YQLYNPETLA NHAMQFGTTT FINDNLTLFF
     TLKREESFHL LDEFTKIPAS MYWWCRFDGQ TELQNGESLF NSEEIIKWLQ HEAVLQGGEL
     TAWPKLLHGD DEMLTWVQET KRLQKKVEGH FPGASEATLA KLKLLGTDCD HEAMTGQEAL
     ARLMQGYTVS LRNSSIRPDL EVLLKELLEL GVKQFDRFIF TTDGSHPSFY ENGMTNIMIA
     TAIKKGIPVI DAYQMASYNI ARYYNMEHIH GAIATGRIAN INILESKENP VPTSVIAKGQ
     WVKRDGVNTH EALHIDWSKC KVTPLSLEWS IEKEDMLFSN KTGIHLLNNV ITKPYTSEIN
     IDCDELSIDY DECFLMMIAR DGTWRVNTVV KGFAKEIGGL ASSYSGTGDI ILVGKRKEDM
     LTAFHRIKEL GGGMVIAEKN EVLHEIALPL LGIMSELKMS ELIQKEKKMV NLLQERGYVY
     NDPAFTILFF SATHLPFIRV TFIGLYDVKS GKVVASPVNL IKQY