Y3037_ARATH
ID Y3037_ARATH Reviewed; 802 AA.
AC Q8LFN2; B0FUP8; Q8GUM9; Q9SRV4;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Probable inactive leucine-rich repeat receptor-like protein kinase At3g03770;
DE Flags: Precursor;
GN OrderedLocusNames=At3g03770; ORFNames=F20H23.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT like protein kinase genes in Arabidopsis thaliana.";
RL BMC Genomics 11:19-19(2010).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-691.
RC STRAIN=cv. Bla-10, cv. Chi-1, cv. Co-1, cv. Columbia, cv. Cvi-0,
RC cv. Da(1)-12, cv. Di-G, cv. Gr-3, cv. Landsberg erecta, cv. Li-3, cv. Mt-0,
RC cv. PHW-1, cv. PHW-32, and cv. Sha;
RX PubMed=18273534; DOI=10.1007/s00239-007-9063-3;
RA Moore R.C., Stevens M.H.H.;
RT "Local patterns of nucleotide polymorphism are highly variable in the
RT selfing species Arabidopsis thaliana.";
RL J. Mol. Evol. 66:116-129(2008).
CC -!- INTERACTION:
CC Q8LFN2; Q8W4S5: At5g63710; NbExp=2; IntAct=EBI-17121194, EBI-16934827;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8LFN2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LFN2-2; Sequence=VSP_040166, VSP_040167;
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF00640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC009540; AAF00640.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73984.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73985.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64316.1; -; Genomic_DNA.
DR EMBL; BT002375; AAO00735.1; -; mRNA.
DR EMBL; FJ708717; ACN59312.1; -; mRNA.
DR EMBL; AY084741; AAM61314.1; -; mRNA.
DR EMBL; EU351279; ABY60312.1; -; Genomic_DNA.
DR EMBL; EU351280; ABY60313.1; -; Genomic_DNA.
DR EMBL; EU351281; ABY60314.1; -; Genomic_DNA.
DR EMBL; EU351282; ABY60315.1; -; Genomic_DNA.
DR EMBL; EU351283; ABY60316.1; -; Genomic_DNA.
DR EMBL; EU351284; ABY60317.1; -; Genomic_DNA.
DR EMBL; EU351285; ABY60318.1; -; Genomic_DNA.
DR EMBL; EU351286; ABY60319.1; -; Genomic_DNA.
DR EMBL; EU351287; ABY60320.1; -; Genomic_DNA.
DR EMBL; EU351288; ABY60321.1; -; Genomic_DNA.
DR EMBL; EU351289; ABY60322.1; -; Genomic_DNA.
DR EMBL; EU351290; ABY60323.1; -; Genomic_DNA.
DR EMBL; EU351291; ABY60324.1; -; Genomic_DNA.
DR EMBL; EU351292; ABY60325.1; -; Genomic_DNA.
DR RefSeq; NP_001189801.1; NM_001202872.1. [Q8LFN2-1]
DR RefSeq; NP_001326355.1; NM_001337482.1. [Q8LFN2-1]
DR RefSeq; NP_566213.1; NM_111248.5. [Q8LFN2-1]
DR AlphaFoldDB; Q8LFN2; -.
DR SMR; Q8LFN2; -.
DR BioGRID; 6497; 37.
DR IntAct; Q8LFN2; 35.
DR STRING; 3702.AT3G03770.1; -.
DR iPTMnet; Q8LFN2; -.
DR PaxDb; Q8LFN2; -.
DR PRIDE; Q8LFN2; -.
DR ProteomicsDB; 232359; -. [Q8LFN2-1]
DR EnsemblPlants; AT3G03770.1; AT3G03770.1; AT3G03770. [Q8LFN2-1]
DR EnsemblPlants; AT3G03770.2; AT3G03770.2; AT3G03770. [Q8LFN2-1]
DR EnsemblPlants; AT3G03770.3; AT3G03770.3; AT3G03770. [Q8LFN2-1]
DR GeneID; 821164; -.
DR Gramene; AT3G03770.1; AT3G03770.1; AT3G03770. [Q8LFN2-1]
DR Gramene; AT3G03770.2; AT3G03770.2; AT3G03770. [Q8LFN2-1]
DR Gramene; AT3G03770.3; AT3G03770.3; AT3G03770. [Q8LFN2-1]
DR KEGG; ath:AT3G03770; -.
DR Araport; AT3G03770; -.
DR TAIR; locus:2079339; AT3G03770.
DR eggNOG; ENOG502QQH1; Eukaryota.
DR HOGENOM; CLU_000288_108_0_1; -.
DR InParanoid; Q8LFN2; -.
DR OMA; RTIMQIC; -.
DR OrthoDB; 309971at2759; -.
DR PhylomeDB; Q8LFN2; -.
DR PRO; PR:Q8LFN2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LFN2; baseline and differential.
DR Genevisible; Q8LFN2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0046777; P:protein autophosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Leucine-rich repeat;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..802
FT /note="Probable inactive leucine-rich repeat receptor-like
FT protein kinase At3g03770"
FT /id="PRO_0000401341"
FT TOPO_DOM 27..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..802
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 71..94
FT /note="LRR 1"
FT REPEAT 104..128
FT /note="LRR 2"
FT REPEAT 129..152
FT /note="LRR 3"
FT REPEAT 153..176
FT /note="LRR 4"
FT REPEAT 177..200
FT /note="LRR 5"
FT REPEAT 201..225
FT /note="LRR 6"
FT REPEAT 227..244
FT /note="LRR 7"
FT REPEAT 245..268
FT /note="LRR 8"
FT REPEAT 269..293
FT /note="LRR 9"
FT REPEAT 294..317
FT /note="LRR 10"
FT REPEAT 319..341
FT /note="LRR 11"
FT DOMAIN 477..759
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 761..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 641..652
FT /note="GQVGSRSGPKGT -> NDDVKSSNVFVS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_040166"
FT VAR_SEQ 653..802
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_040167"
FT CONFLICT 562
FT /note="N -> D (in Ref. 3; AAO00735)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 802 AA; 88187 MW; 0CEEF275F71FF5DE CRC64;
MEKLYCGMPL LLLVLLLASI DGSTQLQSSQ SQTLLRLQQL LYYPKVLNSW NNYTDFCNSE
PSPSLTVVCY EDSVTQLHII GDNGTHMLPK SFSINSFVTT LVKLPDVKVL TFVSLGLWGW
LPQKINRLSS LEILNVSSNF LFGPIPHELS SLATLQTLIL DENMFSGELP DWIDSLPSLA
VLSLRKNVLN GSLPSSLSSL SGLRVLALAN NRFNGALPDL SHLTNLQVLD LEGNSFGPLF
PRLSNKLVTL ILSKNKFRSA VSAEEVSSLY QLQHLDLSYN TFVGPFPTSL MSLPAITYLN
ISHNKLTGRL SANLSCNSQL MFVDMSSNLL TGSLPTCLKP SSGTSRDVVY ASNCLATTNE
DQRPVSFCSN EALAVGILPQ RRNKVSKVGI ALGVTASILG VLLLAGALFV VLRRLNAKKT
VTKSSPRLIR ENASMGYTSK LLSDARYISQ TMKLGGLGLP AYRTFSLEEL EYATNNFESS
AFMGEGSQGQ IYRGRLKDGS FVAIRCLKMK KSCSTQNLMH HIELIAKLRH RHLVSVLGHC
FECYLDDSTV SRMFFVFEYV PNGELRTWIS DGHMGRLLTW EQRISVAIGV AKGIQFLHTG
IVPGVYDNNL KMTDILLDNN LAAKLSSYNL PLLVEGLGKV GQVGSRSGPK GTPSIKDEDK
IDIYDFGVIL LELIVGRPLR AKSQVDVLKE QLQASISADD GARRSMVDPT VHRACSDQSL
KTMMEICVRC LLKDPLERPS IEDVLWNLQF ASQVQEGWLQ NSNPSSNLGS PSPAASSLPP
PSRLHVTTLE SPRDSGCEEH ER
