ID   Y305_METJA              Reviewed;         395 AA.
AC   Q57753;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Uncharacterized protein MJ0305;
GN   OrderedLocusNames=MJ0305;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB98292.1; -; Genomic_DNA.
DR   PIR; B64338; B64338.
DR   AlphaFoldDB; Q57753; -.
DR   SMR; Q57753; -.
DR   STRING; 243232.MJ_0305; -.
DR   TCDB; 2.A.49.4.1; the chloride carrier/channel (clc) family.
DR   EnsemblBacteria; AAB98292; AAB98292; MJ_0305.
DR   KEGG; mja:MJ_0305; -.
DR   eggNOG; arCOG02569; Archaea.
DR   HOGENOM; CLU_015263_5_3_2; -.
DR   InParanoid; Q57753; -.
DR   OMA; NPYYRVL; -.
DR   PhylomeDB; Q57753; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; SSF81340; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..395
FT                   /note="Uncharacterized protein MJ0305"
FT                   /id="PRO_0000094500"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  42618 MW;  9CDC65D6201CF7C0 CRC64;
     MPMNIVNMFG KYIKIIKWIG IASLIGIVGG LSSVIIAIII EYFPEKHNVL LIPIVFFIAG
     LFVDYIYELK GSGIDRVLKA LNTNEKLTWI RGLLKVLLAG AVIAVGGSAG KEGPCVQSSA
     SFADELYRLL KLKNRELVII TGIAGGLGGA FSAPLGTAIL ACEIIEHENF NYINLIPPII
     ASVVGYLIFY LITGRKHLFN ITLSYTINIH DFLLFILGAF FCSLIAHCYI KTYRKISSTF
     DNLKIPYCIK TLIGGILVAV ISYFIPEVMG MGLTLTKELF IMEFSLVFLV LLLIGKILAT
     SFTVGSGTPG GLVFPSMCIG AISGIIFGSL IGDCSAPYIV LGIATTLSAT TNAPLGGAVL
     CTEIFGFDFA VPASIGAVIG YQMTKLETIF KYIRF