Y3084_ARATH
ID Y3084_ARATH Reviewed; 569 AA.
AC Q8LPQ3; F4J211; Q9SVL5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=BTB/POZ domain-containing protein At3g50840;
GN OrderedLocusNames=At3g50840; ORFNames=F18B3_120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB42913.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049862; CAB42913.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78716.1; -; Genomic_DNA.
DR EMBL; AY094473; AAM19841.1; -; mRNA.
DR EMBL; BT004531; AAO42777.1; -; mRNA.
DR PIR; T08405; T08405.
DR RefSeq; NP_190653.2; NM_114944.6.
DR AlphaFoldDB; Q8LPQ3; -.
DR SMR; Q8LPQ3; -.
DR STRING; 3702.AT3G50840.1; -.
DR iPTMnet; Q8LPQ3; -.
DR PaxDb; Q8LPQ3; -.
DR ProteomicsDB; 234600; -.
DR EnsemblPlants; AT3G50840.1; AT3G50840.1; AT3G50840.
DR GeneID; 824248; -.
DR Gramene; AT3G50840.1; AT3G50840.1; AT3G50840.
DR KEGG; ath:AT3G50840; -.
DR Araport; AT3G50840; -.
DR TAIR; locus:2077992; AT3G50840.
DR eggNOG; ENOG502QUA3; Eukaryota.
DR HOGENOM; CLU_005994_6_2_1; -.
DR InParanoid; Q8LPQ3; -.
DR OMA; CDSHARN; -.
DR OrthoDB; 495439at2759; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q8LPQ3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LPQ3; baseline and differential.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03000; NPH3; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..569
FT /note="BTB/POZ domain-containing protein At3g50840"
FT /id="PRO_0000409581"
FT DOMAIN 18..87
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 194..459
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 240..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 400
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9FMF5"
FT CONFLICT 553
FT /note="D -> G (in Ref. 3; AAM19841/AAO42777)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 569 AA; 64301 MW; 1F9A57649F3E6A5B CRC64;
MANSKKQAWF FYTTGLPSDI EIEVDDITFH LHKFPLMSKS KKLHQLITEQ EQSKVYSHIK
LENFPGGSEI FEMVIKISYG FKVDISVSTA VPLRCAAEYL EMTEEYSPEN LISKTEKFLS
EFVFTNVQES IKALKACESV SSLAESLCIT EQCIDSIVFQ ASSTDPSSFY GWPINNGGIF
TVDRKKQSKD SKTELWFEDL TELSFPIFRR VILSMKSSVL SPEIVERSLL TYAKKHIPGI
SRSSSASSSS SSSSTTIASE NQQRELLETI TSDLPLTATT TRSLFGLLRA AIILNASENC
RKFLEKKIGS NLEKATLDDL LIPSYSYLNE TLYDIDLVER LLRRFLENVA VSSSSLTVVG
RLIDGVLGEI ASDANLKPEQ FYNLAVLLPV QARVYDDGLY RAVDIYFKTH SWILEEEKEK
ICSVMDCRKL TVEGCTHAAQ NERLPLRAVV QVLFLEQLQL RQVITGTLLT EEDGDKTVVD
LGRWKEAVKE NQVLRLDMDT MRTRVNQLEK ECLYLKKVIA KIDKESLLKA KHGAGKWSIG
KKFGCKFSAQ VCDSQEATMV DRRSRRFLS
