Y3096_DROME
ID Y3096_DROME Reviewed; 681 AA.
AC Q9VLK2; Q8T9F1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Ribosomal L1 domain-containing protein CG13096;
GN ORFNames=CG13096;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-128, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-17, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL1 family.
CC Highly divergent. {ECO:0000305}.
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DR EMBL; AE014134; AAF52687.1; -; Genomic_DNA.
DR EMBL; AY069795; AAL39940.1; -; mRNA.
DR RefSeq; NP_001285757.1; NM_001298828.1.
DR RefSeq; NP_609236.2; NM_135392.5.
DR AlphaFoldDB; Q9VLK2; -.
DR SMR; Q9VLK2; -.
DR BioGRID; 60303; 12.
DR IntAct; Q9VLK2; 2.
DR STRING; 7227.FBpp0079306; -.
DR iPTMnet; Q9VLK2; -.
DR PaxDb; Q9VLK2; -.
DR PRIDE; Q9VLK2; -.
DR DNASU; 34183; -.
DR EnsemblMetazoa; FBtr0079698; FBpp0079306; FBgn0032050.
DR EnsemblMetazoa; FBtr0343426; FBpp0310071; FBgn0032050.
DR GeneID; 34183; -.
DR KEGG; dme:Dmel_CG13096; -.
DR UCSC; CG13096-RA; d. melanogaster.
DR FlyBase; FBgn0032050; CG13096.
DR VEuPathDB; VectorBase:FBgn0032050; -.
DR eggNOG; KOG1685; Eukaryota.
DR GeneTree; ENSGT00940000172504; -.
DR HOGENOM; CLU_420512_0_0_1; -.
DR InParanoid; Q9VLK2; -.
DR OMA; FSDYRYI; -.
DR OrthoDB; 1000750at2759; -.
DR PhylomeDB; Q9VLK2; -.
DR BioGRID-ORCS; 34183; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG13096; fly.
DR GenomeRNAi; 34183; -.
DR PRO; PR:Q9VLK2; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032050; Expressed in wing disc and 36 other tissues.
DR ExpressionAtlas; Q9VLK2; baseline and differential.
DR Genevisible; Q9VLK2; DM.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR CDD; cd00403; Ribosomal_L1; 1.
DR InterPro; IPR023674; Ribosomal_L1-like.
DR InterPro; IPR028364; Ribosomal_L1/biogenesis.
DR Pfam; PF00687; Ribosomal_L1; 1.
DR SUPFAM; SSF56808; SSF56808; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..681
FT /note="Ribosomal L1 domain-containing protein CG13096"
FT /id="PRO_0000372860"
FT REGION 1..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..681
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 89
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT CONFLICT 23
FT /note="K -> N (in Ref. 3; AAL39940)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 681 AA; 74364 MW; D2BE8A530AD84E96 CRC64;
MVKVQKPQPK SLNKSASIEG VVKKKGKPEK TKKLATDATL ELASNKKAKN AAPVKKDAIK
KEPEVSKKGA EKKQSKAAKR PLILAPPESP AAPAPAAKKS KAKPAASGAP VGKKIEAKKP
LILAPPESPV PPKKQEKKTK AAPVKAKKEP APAKKSVQDP VPSIKKVPAA KKSGQTAALT
KKTAKTEKQA APAKPAKAQP ASQLQKKAKA VQKLSKPASP PKSKKALSKS KPGQAKGNAV
NKEPAKSKKP VELTFELKAF DEKRFHEIVN ENNVTKVCAA LKSVVSEEVE KKKNTSIFSD
YRYVLQVCSY KIPSCPKRMV KLNLKHSLVG KDDDVALIVP DLQRGAKFDY DPTKQHYEDM
LREAGVKQRL TVVPFNQLRN EMGSFEAKRK FLNSYDYLLC DGRLSGQATA FLGKNTQKPR
NVLHSLRLSK DNDKLPQEVT RALTRTAFRQ LSKGDLIAVP VGNHEITAEQ LAENILLVIK
QLQEVYPGGL ANIRSMYLKI DITGTSALPL YVSMCAPPED VPYVVGPREQ RMLKLKKQAN
EVLSKFAMTK DAEFIKLTSD QVKRKAQLRK EKAALLAADA APKDNDGGDA AVPAKKARKE
SSSEGAKADA ESDEEEEVEE AEDSAGESGD EDEEGHDGDD TDEDEDEDDD DDNEDGDDDE
DEDDDEEDDD EEDDDDDDDE E
