Y3120_MYCS2
ID Y3120_MYCS2 Reviewed; 559 AA.
AC A0QWZ7; I7FDB7;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Probable alpha-(1->6)-mannopyranosyltransferase MSMEG_3120/MSMEI_3041;
DE EC=2.4.1.-;
GN OrderedLocusNames=MSMEG_3120, MSMEI_3041;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RX PubMed=18452585; DOI=10.1111/j.1365-2958.2008.06265.x;
RA Mishra A.K., Alderwick L.J., Rittmann D., Wang C., Bhatt A.,
RA Jacobs W.R. Jr., Takayama K., Eggeling L., Besra G.S.;
RT "Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from
RT Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505,
RT affords a lipomannan- and lipoarabinomannan-deficient mutant.";
RL Mol. Microbiol. 68:1595-1613(2008).
CC -!- FUNCTION: Catalyzes the addition of alpha-(1->6)-mannose residue.
CC {ECO:0000269|PubMed:18452585}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:18452585}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene still synthesize
CC lipomannan (LM) and lipoarabinomannan (LAM).
CC {ECO:0000269|PubMed:18452585}.
CC -!- SIMILARITY: Belongs to the MptA/B family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AFP39505.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CP000480; ABK73947.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP39505.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_887435.1; NC_008596.1.
DR AlphaFoldDB; A0QWZ7; -.
DR SMR; A0QWZ7; -.
DR STRING; 246196.MSMEI_3041; -.
DR EnsemblBacteria; ABK73947; ABK73947; MSMEG_3120.
DR EnsemblBacteria; AFP39505; AFP39505; MSMEI_3041.
DR KEGG; msg:MSMEI_3041; -.
DR KEGG; msm:MSMEG_3120; -.
DR PATRIC; fig|246196.19.peg.3081; -.
DR eggNOG; ENOG5032QSS; Bacteria.
DR OMA; MIVWALP; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..559
FT /note="Probable alpha-(1->6)-mannopyranosyltransferase
FT MSMEG_3120/MSMEI_3041"
FT /id="PRO_0000420595"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 535..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 59941 MW; 6F9E69DD3516D514 CRC64;
MMASRLSSFS SSIARWHGDE HAVASPLDDA EILSMRRTRL FGATGTVLMA IGALGAGARP
VVQDPTFGVR LLNLPSRIQT VSLTMTTTGA VMMALAWLML GRYTLGKRRM SRSQLDHTLM
LWTVPLLIAP PMYSRDVYSY LAQSEIAVLG LDPYRVGPAT GLGLDHVFTL SVPNLWRETP
APYGPLFLWI GQGISALTGE NIVEAVMCHR LVVLIGVGLI VWATPRLARR CGVAEVSALW
LGPCNPLLFM HLVAGIHNEA LMLGLMLAGT EFALRGIDAA QPLLPRPLAW PSSRAQWQRW
QPMAMLVLGA VLIAMSSQVK LPSLLALGFV AMALAWRWGG TVKAFVISCT SLGAISLAVM
AVIGWASGLG FGWLFTLGTA NVVRSWMSPP TLIALGTGQV GILLGLGDHT TAVLGLTRAI
GVFMISILVS WLLFAVLRGR LHPVGGLGVA LGGTVLLFPV VQPWYLLWAI IPLAAWATRP
GFRGATIAIT LIVGIFGPTA NGDRFTLFQI VMATLASAVT VLLLIALTYR RLPWRPAPEP
PARPPEQPAP ADDAYAESP
