ID   Y3129_MYCTU             Reviewed;         110 AA.
AC   P9WL05; E0YJK3; F2GJ37; Q6MX08; Q7D628;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Uncharacterized protein Rv3129;
GN   OrderedLocusNames=Rv3129;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=G4B1.2;
RX   PubMed=20639330; DOI=10.1128/jb.00536-10;
RA   Domenech P., Kolly G.S., Leon-Solis L., Fallow A., Reed M.B.;
RT   "Massive gene duplication event among clinical isolates of the
RT   Mycobacterium tuberculosis W/Beijing family.";
RL   J. Bacteriol. 192:4562-4570(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [4]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [5]
RP   INDUCTION BY CARBON MONOXIDE (CO).
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA   Shiloh M.U., Manzanillo P., Cox J.S.;
RT   "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT   macrophage infection.";
RL   Cell Host Microbe 3:323-330(2008).
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC       carbon monoxide (CO). It is hoped that this regulon will give insight
CC       into the latent, or dormant phase of infection.
CC       {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092,
CC       ECO:0000269|PubMed:18474359}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HM053705; ADM62322.1; -; Genomic_DNA.
DR   EMBL; HM053706; ADM62326.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP45939.1; -; Genomic_DNA.
DR   PIR; G70922; G70922.
DR   RefSeq; WP_003416360.1; NZ_NVQJ01000019.1.
DR   AlphaFoldDB; P9WL05; -.
DR   SMR; P9WL05; -.
DR   STRING; 83332.Rv3129; -.
DR   PaxDb; P9WL05; -.
DR   TubercuList; Rv3129; -.
DR   eggNOG; COG3467; Bacteria.
DR   OMA; HYVRITP; -.
DR   PhylomeDB; P9WL05; -.
DR   Proteomes; UP000001584; Chromosome.
DR   Gene3D; 2.30.110.10; -; 1.
DR   InterPro; IPR024747; Pyridox_Oxase-rel.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   Pfam; PF12900; Pyridox_ox_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..110
FT                   /note="Uncharacterized protein Rv3129"
FT                   /id="PRO_0000392939"
SQ   SEQUENCE   110 AA;  12291 MW;  718CC005A6FC7B3D CRC64;
     MVQGRTVLFR TAEGAKLFSA VAKCAVAFEA DDHNVAEGWS VIVKVRAQVL TTDAGVREAE
     RAQLLPWTAT LKRHCVRVIP WEITGRHFRF GPEPDRSQTF ACEASSHNQR