Y3134_MYCTU
ID Y3134_MYCTU Reviewed; 268 AA.
AC P9WFD3; L0TEM6; P95192; Q7D624;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=Universal stress protein Rv3134c;
DE Short=USP Rv3134c;
GN OrderedLocusNames=Rv3134c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP OPERON STRUCTURE.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=10970762; DOI=10.1054/tuld.2000.0240;
RA Dasgupta N., Kapur V., Singh K.K., Das T.K., Sachdeva S., Jyothisri K.,
RA Tyagi J.S.;
RT "Characterization of a two-component system, devR-devS, of Mycobacterium
RT tuberculosis.";
RL Tuber. Lung Dis. 80:141-159(2000).
RN [3]
RP INDUCTION BY HYPOXIA, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=11416222; DOI=10.1073/pnas.121172498;
RA Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA Schoolnik G.K.;
RT "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT encoding alpha -crystallin.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN [4]
RP INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, DORMANCY REGULON, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12953092; DOI=10.1084/jem.20030205;
RA Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA Sherman D.R., Schoolnik G.K.;
RT "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT tuberculosis dormancy program.";
RL J. Exp. Med. 198:705-713(2003).
RN [5]
RP INDUCTION BY CARBON MONOXIDE (CO).
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA Shiloh M.U., Manzanillo P., Cox J.S.;
RT "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT macrophage infection.";
RL Cell Host Microbe 3:323-330(2008).
RN [6]
RP INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA Agarwal A., Steyn A.J.;
RT "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT tuberculosis dormancy regulon.";
RL J. Biol. Chem. 283:18032-18039(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC carbon monoxide (CO). It is hoped that this regulon will give insight
CC into the latent, or dormant phase of infection. Member of the Rv3134c-
CC devR-devS operon. {ECO:0000269|PubMed:11416222,
CC ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:18400743,
CC ECO:0000269|PubMed:18474359}.
CC -!- DISRUPTION PHENOTYPE: A strain lacking this gene does not induce most
CC genes of the dormancy regulon, due to polar effects on the downstream
CC devR (dosR) gene (PubMed:11416222). Restoration of induction only
CC occurs when both this gene and devR (dosR) are transformed into the
CC deleted strain. {ECO:0000269|PubMed:11416222,
CC ECO:0000269|PubMed:12953092}.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP45944.1; -; Genomic_DNA.
DR PIR; G70645; G70645.
DR RefSeq; NP_217650.1; NC_000962.3.
DR RefSeq; WP_003416373.1; NZ_NVQJ01000019.1.
DR AlphaFoldDB; P9WFD3; -.
DR SMR; P9WFD3; -.
DR STRING; 83332.Rv3134c; -.
DR PaxDb; P9WFD3; -.
DR DNASU; 887558; -.
DR GeneID; 45427120; -.
DR GeneID; 887558; -.
DR KEGG; mtu:Rv3134c; -.
DR TubercuList; Rv3134c; -.
DR eggNOG; COG0589; Bacteria.
DR OMA; RDTDCSI; -.
DR PhylomeDB; P9WFD3; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0001666; P:response to hypoxia; IEP:UniProtKB.
DR Gene3D; 3.40.50.620; -; 2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR01438; UNVRSLSTRESS.
PE 1: Evidence at protein level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..268
FT /note="Universal stress protein Rv3134c"
FT /id="PRO_0000392630"
FT BINDING 13
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 107..113
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 117
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 120..121
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
SQ SEQUENCE 268 AA; 28008 MW; EE2CB4F9C9D602AE CRC64;
MSDPRPARAV VVGIDGSRAA THAALWAVDE AVNRDIPLRL VYVIDPSQLS AAGEGGGQSA
ARAALHDASR KVEATGQPVK IETEVLCGRP LTKLMQESRS AAMLCVGSVG LDHVRGRRGS
VAATLAGSAL CPVAVIHPSP AEPATTSQVS AVVAEVDNGV VLRHAFEEAR LRGVPLRAVA
VHAAETPDDV EQGSRLAHVH LSRRLAHWTR LYPEVRVDRA IAGGSACRHL AANAKPGQLF
VADSHSAHEL CGAYQPGCAV LTVRSANL
