ID   Y3137_VIBCH             Reviewed;         334 AA.
AC   O31020; Q9KMK4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Putative carboxypeptidase VC_A0337;
DE            EC=3.4.16.-;
GN   OrderedLocusNames=VC_A0337;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-334.
RC   STRAIN=ATCC 25870 / Classical Inaba 569B / Serotype O1;
RA   Kaewrakon P., Manning P.A.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S66 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB81977.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE003853; AAF96245.1; -; Genomic_DNA.
DR   EMBL; AF025662; AAB81977.1; ALT_INIT; Genomic_DNA.
DR   PIR; H82472; H82472.
DR   RefSeq; NP_232733.1; NC_002506.1.
DR   RefSeq; WP_000964920.1; NZ_LT906615.1.
DR   AlphaFoldDB; O31020; -.
DR   SMR; O31020; -.
DR   STRING; 243277.VC_A0337; -.
DR   MEROPS; S66.003; -.
DR   DNASU; 2612508; -.
DR   EnsemblBacteria; AAF96245; AAF96245; VC_A0337.
DR   GeneID; 57741836; -.
DR   KEGG; vch:VC_A0337; -.
DR   PATRIC; fig|243277.26.peg.2971; -.
DR   eggNOG; COG1619; Bacteria.
DR   HOGENOM; CLU_034346_1_1_6; -.
DR   OMA; GFIFGQC; -.
DR   BioCyc; VCHO:VCA0337-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10740; -; 1.
DR   Gene3D; 3.50.30.60; -; 1.
DR   InterPro; IPR027461; Carboxypeptidase_A_C_sf.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR027478; LdcA_N.
DR   InterPro; IPR040449; Peptidase_S66_N.
DR   InterPro; IPR040921; Peptidase_S66C.
DR   InterPro; IPR003507; S66_fam.
DR   PANTHER; PTHR30237; PTHR30237; 1.
DR   Pfam; PF02016; Peptidase_S66; 1.
DR   Pfam; PF17676; Peptidase_S66C; 1.
DR   PIRSF; PIRSF028757; LD-carboxypeptidase; 1.
DR   SUPFAM; SSF141986; SSF141986; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase; Hydrolase; Protease; Reference proteome; Serine protease.
FT   CHAIN           1..334
FT                   /note="Putative carboxypeptidase VC_A0337"
FT                   /id="PRO_0000172848"
FT   ACT_SITE        112
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        234
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        302
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   334 AA;  37274 MW;  047FF819753FE440 CRC64;
     MLYAKALSIG DEIGFFSPSS PATAFAPNRF QRAKAYLKAQ GFELVEGSLT GKSDYYRSGS
     IRERAEELNQ LIRDPNVRCI MPTIGGNNSN SLLPYIDYEA LRNDPKIIIG YSDVTALLLG
     IYAQTGLITF YGPALVASFG EYPPLVDETF HSFIDLLCSE TNQYQYTMPS SWTDIKHDWE
     TQHSAKPVYP NEWQFIGKGK VTGRIIGGNL NTMAGIWGSR YMPEIKVGDI LLIEDSLKGI
     ENVERSFAHL AACGVFERVS AIILGKHELF DNKGTGRTPL DVLIEVLADK NVPIFYGFDS
     CHTHPMLVTP LGVRGTIDFD NHTFKLEDRW VKAK