ID   Y3143_MYCTU             Reviewed;         133 AA.
AC   P9WGL7; L0TEN7; P95183; Q7D616;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Uncharacterized response regulatory protein Rv3143;
GN   OrderedLocusNames=Rv3143;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, DETERMINATION OF TRANSLATIONAL START
RP   SITE, AND CLEAVAGE OF INITIATOR METHIONINE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17259624; DOI=10.1099/mic.0.2006/001537-0;
RA   Rison S.C., Mattow J., Jungblut P.R., Stoker N.G.;
RT   "Experimental determination of translational starts using peptide mass
RT   mapping and tandem mass spectrometry within the proteome of Mycobacterium
RT   tuberculosis.";
RL   Microbiology 153:521-528(2007).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP45954.1; -; Genomic_DNA.
DR   PIR; H70646; H70646.
DR   RefSeq; NP_217659.1; NC_000962.3.
DR   RefSeq; WP_003416410.1; NZ_NVQJ01000019.1.
DR   AlphaFoldDB; P9WGL7; -.
DR   SMR; P9WGL7; -.
DR   STRING; 83332.Rv3143; -.
DR   PaxDb; P9WGL7; -.
DR   DNASU; 887576; -.
DR   GeneID; 45427130; -.
DR   GeneID; 887576; -.
DR   KEGG; mtu:Rv3143; -.
DR   TubercuList; Rv3143; -.
DR   eggNOG; COG0784; Bacteria.
DR   OMA; AWLASWS; -.
DR   PhylomeDB; P9WGL7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Two-component regulatory system.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:17259624"
FT   CHAIN           2..133
FT                   /note="Uncharacterized response regulatory protein Rv3143"
FT                   /id="PRO_0000403682"
FT   DOMAIN          9..128
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         64
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   133 AA;  14386 MW;  57DF1E50B20F655D CRC64;
     MPDSSTALRI LVYSDNVQTR ERVMRALGKR LHPDLPDLTY VEVATGPMVI RQMDRGGIDL
     AILDGEATPT GGMGIAKQLK DELASCPPIL VLTGRPDDTW LASWSRAEAA VPHPVDPIVL
     GRTVLSLLRA PAH