Y3184_DICDI
ID Y3184_DICDI Reviewed; 1186 AA.
AC Q54C77;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable inactive serine/threonine-protein kinase DDB_G0293184;
GN ORFNames=DDB_G0293184;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive as it lacks an expected active site aspartate residue.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. {ECO:0000250|UniProtKB:Q54QI2}.
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DR EMBL; AAFI02000199; EAL60944.1; -; Genomic_DNA.
DR RefSeq; XP_629342.1; XM_629340.1.
DR AlphaFoldDB; Q54C77; -.
DR SMR; Q54C77; -.
DR STRING; 44689.DDB0229972; -.
DR PaxDb; Q54C77; -.
DR PRIDE; Q54C77; -.
DR EnsemblProtists; EAL60944; EAL60944; DDB_G0293184.
DR GeneID; 8629066; -.
DR KEGG; ddi:DDB_G0293184; -.
DR dictyBase; DDB_G0293184; -.
DR eggNOG; KOG0198; Eukaryota.
DR eggNOG; KOG4269; Eukaryota.
DR HOGENOM; CLU_272428_0_0_1; -.
DR InParanoid; Q54C77; -.
DR OMA; KRTNQMA; -.
DR Reactome; R-DDI-75153; Apoptotic execution phase.
DR PRO; PR:Q54C77; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; GTPase activation; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1186
FT /note="Probable inactive serine/threonine-protein kinase
FT DDB_G0293184"
FT /id="PRO_0000370210"
FT DOMAIN 173..437
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT DOMAIN 1004..1186
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 631..659
FT /evidence="ECO:0000255"
FT COILED 875..909
FT /evidence="ECO:0000255"
FT COMPBIAS 28..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..187
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P28523,
FT ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 205
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250|UniProtKB:P28523,
FT ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1186 AA; 134168 MW; 287F58A8B14EDEEC CRC64;
MEQEDQQYEE DSSQFNKNNY VPDDNSGEKE QPATTTEITT TTTTTTPTAI DNNDSDLTED
VINAVSKYKD GTSSKSVKKT RRKFAMNIAT DEVFNLPPME QQQQQQHLQP PLSPNSASNT
NFGAAATFSP TSILSKNNKI ITSQQTSSTS ISPLKPSPLS FSSGILPPSS RIYESPPTLG
KYDKVILVIL SQQYLQNQVN IFPIKLIDRE RINLIHQNIL SNEFQLLKSL KHSGIVNYIG
MINDNTGFGI VQEFYENGSL SDIYNRSGAF QESLVAKYTL QILEALGYIH SQGIVHRNLK
SNNVLLAKGG KVKISDFAIG IRSSAIEPSI RFSLNGYPFW TSPEVLSMKP FNHKVDSWSI
GCLIMELIVG HPPFSHLGPM EALIEIINPS TTILPNCLDE NEQSLFSLEL NQFLELCFKK
EPSDRASVHD LLRHPWLSMF NDSSSSSSSS SSQAHPTVQS NNLNGNVNSR THGEFYSLDF
LSQFEQNEKE ISKILSSGDQ LDSTSNQIDL KKFQFKHYNK KQQQQYNYNY NNYNNNNNNN
NNTNDNDNEC GEQTEEINLS SLSKDEQIER LKAIIDQNET MANNLKYTMQ EVLQEQTKYY
EICESMKSKT LEILNQNKTG ARISAHSNSL LKRTNQMAND LGRKYEILQS NIKRLEDYLI
TKDDCAKKLA NVVYRNKISF DSLLNPTLAA NLLYQIGSKT WKKGQEKRAF ATLKDNFLFF
FKNEKSSYPI DVIYLNDKRN ISITSIQDSK KKAYIICIGT TIHDQNNLDP SNNNESVNLS
TSPGSLVNSN SNPSISNSLN NNNNNNNNNN NNNNGNPNVI ITTNNNCNSN SNGNNIATPP
ISIPNGKEVK EGKEIKEIKE PKEKDKDKEK DKDKEKDKDK EKDKDKEKEK DKDKENNNNN
NSNNNNNNGN NYNSSETIWC LLAFDNSKNM ENWYGVLDSV VPWYDKRAYE ISKPMLPIEN
KKHQKQKSLD STNKQSPGSL GGAGGDVSWK KESGGIKFQG VVGVRLDDLM TRESPTAELP
YFLSKMLKFL EKNVDEEGIL RLSGSSTEIL EMKQQLQRGE SIDYTYKDPH AVTGLLKLFL
RELPESILPE HLRIQSTEIL SNGRFGEKEK IKEIQTLLSN LSRPHYNVLK HMLFFAKLVV
DRSEYNKMVI ANVTTCFSPT LRIPPGLFNF LINTYDLSFP KFNLSV
