ID   Y3188_MYCTU             Reviewed;         115 AA.
AC   O53334; F2GJP3; I6X6L9; Q7D5Z2;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Probable mycobacterial cidal antitoxin Rv3188 {ECO:0000250|UniProtKB:P9WLP7};
GN   OrderedLocusNames=Rv3188;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007744|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   DISCUSSION OF POSSIBLE FUNCTION.
RC   STRAIN=H37Rv;
RX   PubMed=30598453; DOI=10.1073/pnas.1814633116;
RA   Piscotta F.J., Jeffrey P.D., Link A.J.;
RT   "ParST is a widespread toxin-antitoxin module that targets nucleotide
RT   metabolism.";
RL   Proc. Natl. Acad. Sci. U.S.A. 116:826-834(2019).
CC   -!- FUNCTION: Probable antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Neutralizes the activity of cognate toxin Rv3189 by
CC       blocking access to the toxin active site.
CC       {ECO:0000250|UniProtKB:P9WLP7, ECO:0000305|PubMed:30598453}.
CC   -!- SUBUNIT: Forms a heterotetramer with cognate toxin Rv3189.
CC       {ECO:0000250|UniProtKB:P9WLP9}.
CC   -!- SIMILARITY: Belongs to the MbcA/ParS/Xre antitoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45999.1; -; Genomic_DNA.
DR   RefSeq; NP_217704.1; NC_000962.3.
DR   RefSeq; WP_003899956.1; NZ_NVQJ01000003.1.
DR   AlphaFoldDB; O53334; -.
DR   SMR; O53334; -.
DR   STRING; 83332.Rv3188; -.
DR   PaxDb; O53334; -.
DR   PRIDE; O53334; -.
DR   DNASU; 888103; -.
DR   GeneID; 45427173; -.
DR   GeneID; 888103; -.
DR   KEGG; mtu:Rv3188; -.
DR   PATRIC; fig|83332.111.peg.3552; -.
DR   TubercuList; Rv3188; -.
DR   eggNOG; ENOG5030YRK; Bacteria.
DR   PhylomeDB; O53334; -.
DR   Proteomes; UP000001584; Chromosome.
DR   InterPro; IPR024467; Xre/MbcA/ParS-like_toxin-bd.
DR   Pfam; PF09722; DUF2384; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..115
FT                   /note="Probable mycobacterial cidal antitoxin Rv3188"
FT                   /id="PRO_0000448604"
SQ   SEQUENCE   115 AA;  12818 MW;  EE5D945B1F839517 CRC64;
     MAVTLDRAVE ASEIVDALKP FGVTQVDVAA VIQVSDRAVR GWRTGDIRPE RYDRLAQLRD
     LVLLLSDSLT PRGVGQWLHA KNRLLDGQRP VDLLAKDRYE DVRSAAESFI DGAYV