ID   Y3193_MYCTU             Reviewed;         992 AA.
AC   P9WFL3; L0TEL2; O53339;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=UPF0182 protein Rv3193c {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=Rv3193c; ORFNames=MTV014.37c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; AL123456; CCP46005.1; -; Genomic_DNA.
DR   PIR; G70950; G70950.
DR   RefSeq; NP_217709.1; NC_000962.3.
DR   RefSeq; WP_003899961.1; NZ_NVQJ01000003.1.
DR   AlphaFoldDB; P9WFL3; -.
DR   SMR; P9WFL3; -.
DR   STRING; 83332.Rv3193c; -.
DR   PaxDb; P9WFL3; -.
DR   DNASU; 888012; -.
DR   GeneID; 888012; -.
DR   KEGG; mtu:Rv3193c; -.
DR   TubercuList; Rv3193c; -.
DR   eggNOG; COG1615; Bacteria.
DR   OMA; HLRYPQD; -.
DR   PhylomeDB; P9WFL3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..992
FT                   /note="UPF0182 protein Rv3193c"
FT                   /id="PRO_0000157724"
FT   TRANSMEM        17..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        59..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        113..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        212..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        255..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        284..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          906..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        912..936
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   992 AA;  107502 MW;  EF0F09B7B064261E CRC64;
     MGMRSAARMP KLTRRSRILI MIALGVIVLL LAGPRLIDAY VDWLWFGELG YRSVFTTMLA
     TRIVVCLVAG VVVGGIVFGG LALAYRTRPV FVPDADNDPV ARYRAVVLAR LRLVGIGIPA
     AIGLLAGIVA QSYWARIQLF LHGGDFGVRD PQFGRDLGFY AFELPFYRLM LSYMLVSVFL
     AFVANLVAHY IFGGIRLSGR TGALSRSARV QLVSLVGVLV LLKAVAYWLD RYELLSHTRG
     GKPFTGAGYT DINAVLPAKL ILMAIALICA AAVFSAIALR DLRIPAIGLV LLLLSSLIVG
     AGWPLIVEQI SVKPNAAQKE SEYISRSITA TRQAYGLTSD VVTYRNYSGD SPATAQQVAA
     DRATTSNIRL LDPTIVSPAF TQFQQGKNFY YFPDQLSIDR YLDRNGNLRD YVVAARELNP
     DRLIDNQRDW INRHTVYTHG NGFIASPANT VRGIANDPNQ NGGYPEFLVN VVGANGTVVS
     DGPAPLDQPR IYFGPVISNT SADYAIVGRN GDDREYDYET NIDTKRYTYT GSGGVPLGGW
     LARSVFAAKF AERNFLFSNV IGSNSKILFN RDPAQRVEAV APWLTTDSAV YPAIVNKRLV
     WIVDGYTTLD NYPYSELTSL SSATADSNEV AFNRLVPDKK VSYIRNSVKA TVDAYDGTVT
     LYQQDEKDPV LKAWMQVFPG TVKPKSDIAP ELAEHLRYPE DLFKVQRMLL AKYHVNDPVT
     FFSTSDFWDV PLDPNPTASS YQPPYYIVAK NIAKDDNSAS YQLISAMNRF KRDYLAAYIS
     ASSDPATYGN LTVLTIPGQV NGPKLANNAI TTDPAVSQDL GVIGRDNQNR IRWGNLLTLP
     VARGGLLYVE PVYASPGASD AASSYPRLIR VAMMYNDKVG YGPTVRDALT GLFGPGAGAT
     ATGIAPTEAA VPPSPAANPP PPASGPQPPP VTAAPPVPVG AVTLSPAKVA ALQEIQAAIG
     AARDAQKKGD FAAYGSALQR LDEAITKFND AG