ID   Y31E_CAEEL              Reviewed;         441 AA.
AC   Q8MYQ1; Q8MYQ2; Q95QH8;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Putative serine/threonine-protein kinase F31E3.2;
DE            EC=2.7.11.1;
GN   ORFNames=F31E3.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000250|UniProtKB:P00517};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P00517};
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a {ECO:0000303|PubMed:9851916};
CC         IsoId=Q8MYQ1-1; Sequence=Displayed;
CC       Name=b {ECO:0000303|PubMed:9851916};
CC         IsoId=Q8MYQ1-2; Sequence=VSP_051610;
CC       Name=c {ECO:0000303|PubMed:9851916};
CC         IsoId=Q8MYQ1-3; Sequence=VSP_051608, VSP_051609;
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; FO080392; CCD63402.1; -; Genomic_DNA.
DR   EMBL; FO080392; CCD63403.1; -; Genomic_DNA.
DR   EMBL; FO080392; CCD63404.1; -; Genomic_DNA.
DR   RefSeq; NP_001022557.1; NM_001027386.3. [Q8MYQ1-2]
DR   RefSeq; NP_001022558.1; NM_001027387.2. [Q8MYQ1-3]
DR   RefSeq; NP_498522.3; NM_066121.4. [Q8MYQ1-1]
DR   AlphaFoldDB; Q8MYQ1; -.
DR   SMR; Q8MYQ1; -.
DR   BioGRID; 41191; 8.
DR   DIP; DIP-25224N; -.
DR   IntAct; Q8MYQ1; 5.
DR   STRING; 6239.F31E3.2a; -.
DR   EPD; Q8MYQ1; -.
DR   PaxDb; Q8MYQ1; -.
DR   EnsemblMetazoa; F31E3.2a.1; F31E3.2a.1; WBGene00017950. [Q8MYQ1-1]
DR   EnsemblMetazoa; F31E3.2b.1; F31E3.2b.1; WBGene00017950. [Q8MYQ1-2]
DR   EnsemblMetazoa; F31E3.2c.1; F31E3.2c.1; WBGene00017950. [Q8MYQ1-3]
DR   GeneID; 175977; -.
DR   KEGG; cel:CELE_F31E3.2; -.
DR   UCSC; F31E3.2c; c. elegans. [Q8MYQ1-1]
DR   CTD; 175977; -.
DR   WormBase; F31E3.2a; CE30773; WBGene00017950; -. [Q8MYQ1-1]
DR   WormBase; F31E3.2b; CE30774; WBGene00017950; -. [Q8MYQ1-2]
DR   WormBase; F31E3.2c; CE29301; WBGene00017950; -. [Q8MYQ1-3]
DR   eggNOG; KOG0694; Eukaryota.
DR   GeneTree; ENSGT00940000160082; -.
DR   InParanoid; Q8MYQ1; -.
DR   OMA; VNFVMET; -.
DR   OrthoDB; 694650at2759; -.
DR   PhylomeDB; Q8MYQ1; -.
DR   PRO; PR:Q8MYQ1; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00017950; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR   CDD; cd05123; STKc_AGC; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR045270; STKc_AGC.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; ATP-binding; Kinase; Nucleotide-binding;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..441
FT                   /note="Putative serine/threonine-protein kinase F31E3.2"
FT                   /id="PRO_0000086827"
FT   DOMAIN          126..381
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        253
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P00517,
FT                   ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-
FT                   ProRule:PRU10027"
FT   BINDING         132..140
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P00517,
FT                   ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         156
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P00517,
FT                   ECO:0000255|PROSITE-ProRule:PRU00159"
FT   VAR_SEQ         95..102
FT                   /note="PEPTRKEF -> RMFCCIMR (in isoform c)"
FT                   /evidence="ECO:0000303|PubMed:9851916"
FT                   /id="VSP_051608"
FT   VAR_SEQ         103..441
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000303|PubMed:9851916"
FT                   /id="VSP_051609"
FT   VAR_SEQ         426..441
FT                   /note="VSCGRNVIFAVLPVFW -> FDRFDYFNDRF (in isoform b)"
FT                   /evidence="ECO:0000303|PubMed:9851916"
FT                   /id="VSP_051610"
SQ   SEQUENCE   441 AA;  50598 MW;  0F510A0B3D9563B1 CRC64;
     MGNVATRKRP GCHHHIGRNE ENLDDDEDGP AKKRLRIGEP QAENEYQKLA FKSRLQKLKK
     CRPHLKRRTY KVEEADPRPP VPRFIVDDYG DYEKPEPTRK EFAIPWFEHL FLPEFPTRSV
     INEKSFVLER QLGRGSFGVV YCASAIHDSE RKFAIKMQEK REIISKRAVL QVKREASIQR
     LLPSHPFIAR TYSTWQTRTH LYSLLQYPTG STGDLFSVWR QRGSLSEAAI RLIGAELASA
     IDFLHQNDVI YRDVKLENVV LDQWGHALLI DFGLAKKLKQ GSSTGTICGT LQYMSPDVAS
     GGTYSHYVDW WSLGVLLHIL LTGIYPYPNS EATHHANLKF IDYSTPIGCS REFANLMDRM
     LAVSITHRLC SFTVLHAHPF FRSIDFSKLE QKDYTPAAEI GNAEYDTYHK SEDALDDALF
     KENYDVSCGR NVIFAVLPVF W