ID   Y3202_DICDI             Reviewed;         437 AA.
AC   Q54C11;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0293202;
GN   ORFNames=DDB_G0293202;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA   Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA   Ivens A., Martinez J.L., Escalante R.;
RT   "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT   and specific effects from PAO1 and PA14 strains.";
RL   BMC Microbiol. 8:109-109(2008).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Up-regulated by Pseudomonas aeruginosa, PAO1 strain and
CC       down-regulated by PA14 strain infection. {ECO:0000269|PubMed:18590548}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000200; EAL60800.1; -; Genomic_DNA.
DR   RefSeq; XP_629255.1; XM_629253.1.
DR   AlphaFoldDB; Q54C11; -.
DR   SMR; Q54C11; -.
DR   STRING; 44689.DDB0237662; -.
DR   PaxDb; Q54C11; -.
DR   EnsemblProtists; EAL60800; EAL60800; DDB_G0293202.
DR   GeneID; 8629137; -.
DR   KEGG; ddi:DDB_G0293202; -.
DR   dictyBase; DDB_G0293202; trafH.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54C11; -.
DR   OMA; HIDEECL; -.
DR   PhylomeDB; Q54C11; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54C11; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..437
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0293202"
FT                   /id="PRO_0000393764"
FT   DOMAIN          303..422
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         126..181
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         182..239
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   COILED          240..287
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   437 AA;  49925 MW;  1949E73C03D88118 CRC64;
     MDVNIFHFLF TKTNPGENFS CPKCKILIYD FDKVSEVYQC KNGSWACKNC WIEIFRTTKE
     CPTKECRVES IDSLSRSRFI ENGFAGKNMD CPNSLVRSNP NHYEGINVLL DDDGCRDVVT
     VGNLSSHLKG CIYAFTKCPN DVNGCTGEFR LKNLDQHLQT CGFQLEDCPN CNNKIIRKSI
     EEHIDEECLK TKIKCLECGS TVERGDMDFH LDNVCPNIVI PCILCDNGCD LLFKRSELSN
     HLQSIEHISN LNNKIDELNE TLNDLQISEL NQKVEQLETL LTQARDDPLA QREINRLISK
     QEKFKSVWDI KNFSKRQFQK GFYFSSPVIT VGHHSFHLWL YPNGETSPSN SLSLYLVLTK
     GEKTFVNFSI SIKNHNGNDL NSTFENDKCL EVGGTRWGWA FEKDFKTGGY LKNDTLSIQF
     TVAIKKQPLI TDILSVQ