Y3210_ARATH
ID Y3210_ARATH Reviewed; 506 AA.
AC Q9C5J4; Q9LIF0;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=BTB/POZ domain-containing protein At3g22104;
GN OrderedLocusNames=At3g22104; ORFNames=MZN24.32;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB03059.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP001306; BAB03059.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB028622; BAB03059.1; JOINED; Genomic_DNA.
DR EMBL; CP002686; AEE76590.1; -; Genomic_DNA.
DR EMBL; AF360210; AAK25920.1; -; mRNA.
DR EMBL; AY040058; AAK64116.1; -; mRNA.
DR RefSeq; NP_001327524.1; NM_001338562.1.
DR RefSeq; NP_001327525.1; NM_001338561.1.
DR RefSeq; NP_001327526.1; NM_001338563.1.
DR RefSeq; NP_188849.3; NM_113107.7.
DR AlphaFoldDB; Q9C5J4; -.
DR SMR; Q9C5J4; -.
DR STRING; 3702.AT3G22104.1; -.
DR iPTMnet; Q9C5J4; -.
DR PaxDb; Q9C5J4; -.
DR PRIDE; Q9C5J4; -.
DR ProteomicsDB; 234632; -.
DR EnsemblPlants; AT3G22104.1; AT3G22104.1; AT3G22104.
DR GeneID; 821773; -.
DR Gramene; AT3G22104.1; AT3G22104.1; AT3G22104.
DR KEGG; ath:AT3G22104; -.
DR Araport; AT3G22104; -.
DR TAIR; locus:2095637; AT3G22104.
DR eggNOG; ENOG502QW1N; Eukaryota.
DR HOGENOM; CLU_005994_8_0_1; -.
DR InParanoid; Q9C5J4; -.
DR OMA; RCAAEFM; -.
DR OrthoDB; 690295at2759; -.
DR PhylomeDB; Q9C5J4; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9C5J4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9C5J4; baseline and differential.
DR Genevisible; Q9C5J4; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF03000; NPH3; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..506
FT /note="BTB/POZ domain-containing protein At3g22104"
FT /id="PRO_0000409576"
FT DOMAIN 6..76
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 187..435
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 485..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..492
FT /evidence="ECO:0000255"
SQ SEQUENCE 506 AA; 57385 MW; 8FB15E65B5A229D2 CRC64;
MEACCSDLEV DINGEQTIFL NKQIICAYSG TLRKLLGKST SSSGNLKVIF NDFPGGAESF
EFVSRFCYND GRVAVMPSNV VFLHCAAKFM EVTKVLEQTE KCMEEIRYWA WPEVLLCLKQ
CQEVETSPEV DSLAAKLMDA LVEKLCLTIE MSPSSAGSAC SPDSSLFRFS CDSKSTESFK
NCSVRLTWWF DEVLVLSSGL VEMFLKLMVL RKFDNLIISR FLFYYQKVKF CSASSHEKRK
ILETIIDTLC VLDRSCVPCK SLFAVLRLAL GLNINKSCMN KLEVMIGHQL DQATLDNLLV
PSPSKSSHLY YVNLVLRFTK AFLDGARSGL QLKKVSSLID QYIAEVAPDP CLKPSKFLSL
ITLVPDSARE SHEDIYRAID MYLEAHTGTT DGEKLNLIRT LSYEKLSGES RAHISRNQKF
QAIETLDEQQ QQQQQQQQQK QLILRMEKVE TSGENEKLKE HIEGIQWRVM ELERACLKMQ
NQMEVIKKRS KSSSKGSNRS LPKLCS
