ID   Y321_MYCBP              Reviewed;         302 AA.
AC   A1KFA4;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase BCG_0321;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=BCG_0321;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AM408590; CAL70306.1; -; Genomic_DNA.
DR   RefSeq; WP_003401448.1; NC_008769.1.
DR   AlphaFoldDB; A1KFA4; -.
DR   SMR; A1KFA4; -.
DR   KEGG; mbb:BCG_0321; -.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; NEQCAPA; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..302
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase BCG_0321"
FT                   /id="PRO_0000361145"
FT   BINDING         126
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         155..156
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   302 AA;  32998 MW;  E61B7CC197AE2782 CRC64;
     MRTEGDSWDI TTSVGSTALF VATARALEAQ KSDPLVVDPY AEAFCRAVGG SWADVLDGKL
     PDHKLKSTDF GEHFVNFQGA RTKYFDEYFR RAAAAGARQV VILAAGLDSR AYRLPWPDGT
     TVFELDRPQV LDFKREVLAS HGAQPRALRR EIAVDLRDDW PQALRDSGFD AAAPSAWIAE
     GLLIYLPATA QERLFTGIDA LAGRRSHVAV EDGAPMGPDE YAAKVEEERA AIAEGAEEHP
     FFQLVYNERC APAAEWFGER GWTAVATLLN DYLEAVGRPV PGPESEAGPM FARNTLVSAA
     RV