ID   Y3227_MYCTA             Reviewed;         992 AA.
AC   A5U7L0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=UPF0182 protein MRA_3227 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=MRA_3227;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; CP000611; ABQ75010.1; -; Genomic_DNA.
DR   RefSeq; WP_003899961.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U7L0; -.
DR   SMR; A5U7L0; -.
DR   STRING; 419947.MRA_3227; -.
DR   EnsemblBacteria; ABQ75010; ABQ75010; MRA_3227.
DR   KEGG; mra:MRA_3227; -.
DR   eggNOG; COG1615; Bacteria.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   OMA; HLRYPQD; -.
DR   OrthoDB; 170146at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..992
FT                   /note="UPF0182 protein MRA_3227"
FT                   /id="PRO_0000323478"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          906..938
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        912..936
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   992 AA;  107502 MW;  EF0F09B7B064261E CRC64;
     MGMRSAARMP KLTRRSRILI MIALGVIVLL LAGPRLIDAY VDWLWFGELG YRSVFTTMLA
     TRIVVCLVAG VVVGGIVFGG LALAYRTRPV FVPDADNDPV ARYRAVVLAR LRLVGIGIPA
     AIGLLAGIVA QSYWARIQLF LHGGDFGVRD PQFGRDLGFY AFELPFYRLM LSYMLVSVFL
     AFVANLVAHY IFGGIRLSGR TGALSRSARV QLVSLVGVLV LLKAVAYWLD RYELLSHTRG
     GKPFTGAGYT DINAVLPAKL ILMAIALICA AAVFSAIALR DLRIPAIGLV LLLLSSLIVG
     AGWPLIVEQI SVKPNAAQKE SEYISRSITA TRQAYGLTSD VVTYRNYSGD SPATAQQVAA
     DRATTSNIRL LDPTIVSPAF TQFQQGKNFY YFPDQLSIDR YLDRNGNLRD YVVAARELNP
     DRLIDNQRDW INRHTVYTHG NGFIASPANT VRGIANDPNQ NGGYPEFLVN VVGANGTVVS
     DGPAPLDQPR IYFGPVISNT SADYAIVGRN GDDREYDYET NIDTKRYTYT GSGGVPLGGW
     LARSVFAAKF AERNFLFSNV IGSNSKILFN RDPAQRVEAV APWLTTDSAV YPAIVNKRLV
     WIVDGYTTLD NYPYSELTSL SSATADSNEV AFNRLVPDKK VSYIRNSVKA TVDAYDGTVT
     LYQQDEKDPV LKAWMQVFPG TVKPKSDIAP ELAEHLRYPE DLFKVQRMLL AKYHVNDPVT
     FFSTSDFWDV PLDPNPTASS YQPPYYIVAK NIAKDDNSAS YQLISAMNRF KRDYLAAYIS
     ASSDPATYGN LTVLTIPGQV NGPKLANNAI TTDPAVSQDL GVIGRDNQNR IRWGNLLTLP
     VARGGLLYVE PVYASPGASD AASSYPRLIR VAMMYNDKVG YGPTVRDALT GLFGPGAGAT
     ATGIAPTEAA VPPSPAANPP PPASGPQPPP VTAAPPVPVG AVTLSPAKVA ALQEIQAAIG
     AARDAQKKGD FAAYGSALQR LDEAITKFND AG