ID   Y323_BUCAI              Reviewed;         521 AA.
AC   P57408;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=UPF0053 protein BU323;
GN   OrderedLocusNames=BU323;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; BA000003; BAB13031.1; -; Genomic_DNA.
DR   RefSeq; NP_240145.1; NC_002528.1.
DR   RefSeq; WP_010896066.1; NC_002528.1.
DR   AlphaFoldDB; P57408; -.
DR   SMR; P57408; -.
DR   STRING; 107806.10038997; -.
DR   PRIDE; P57408; -.
DR   EnsemblBacteria; BAB13031; BAB13031; BAB13031.
DR   KEGG; buc:BU323; -.
DR   PATRIC; fig|107806.10.peg.335; -.
DR   eggNOG; COG1253; Bacteria.
DR   HOGENOM; CLU_015237_0_0_6; -.
DR   OMA; EFGVIQG; -.
DR   BioCyc; BAPH107806:GBZJ-316-MON; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR005496; Integral_membrane_TerC.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF03741; TerC; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..521
FT                   /note="UPF0053 protein BU323"
FT                   /id="PRO_0000088375"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          311..370
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          374..434
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   521 AA;  58723 MW;  E6D9E406600DD958 CRC64;
     MEFFLDPSTW AGLLTLVILE VVLGIDNLIF VAILSEKLPP NQRDKARLIG LGLALVMRLA
     LLSLISWIVT LNSPIVHNKF FSLSIRDIIL LFGGFFLLFK TTMELHERLE NNHHENSENK
     NYAGFWAVVI QIVVLDAVFS LDAIITAVGM VNQLLIMMIA VILATFLMLL ASKALTNFIN
     LHQTVVVLCL SFLLMIGFSL VTEALRFCIP KGYLYAAIGF SILIEIFNQI ARHNFMKNQS
     RRPMRQRAAE AILRLMVGEQ NKKQQIKKIE INSQKTDSIQ SSKEMETFKD EERYMINGVL
     TLAGRSIRSI MTPRSNISWV NTEKNTDEIR MQLLDTPHSL FPVCKGELDE IIGIVRAKEL
     LVAIEKKIDA STFSSKILPI IIPDTLDPIK LLGVLRRAQG SFVIVSNEFG VVQGLITPLD
     VLEAIAGEFP DADETPDIIQ ENNSWLVKGE TDLHSLQQLL NTEELIKEDN YASLGGLLIA
     QKGQLPIPGE IIHIHPFYFH IVKATEYRID LVRIIKNQDD N