Y3254_MYCTU
ID Y3254_MYCTU Reviewed; 474 AA.
AC O05897; I6XGQ4; L0TC96;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-2015, sequence version 4.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein Rv3254 {ECO:0000305};
DE Flags: Precursor;
GN OrderedLocusNames=Rv3254 {ECO:0000312|EMBL:CCP46073.1},
GN RVBD_3254 {ECO:0000312|EMBL:AFN51259.1};
GN ORFNames=P425_03394 {ECO:0000312|EMBL:KBJ28301.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K.,
RA Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T.,
RA Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PROTEIN SEQUENCE OF 5-26, AND SEQUENCE REVISION TO N-TERMINUS.
RC STRAIN=H37Rv;
RX PubMed=34915127; DOI=10.1016/j.ygeno.2021.12.001;
RA Shi J., Meng S., Wan L., Zhang Z., Jiang S., Zhu H., Dai E., Chang L.,
RA Gao H., Wan K., Zhang L., Zhao X., Liu H., Lyu Z., Zhang Y., Xu P.;
RT "Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct
RT annotated encoding genes.";
RL Genomics 114:292-304(2021).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SEQUENCE CAUTION:
CC Sequence=AFN51259.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
CC Sequence=CCP46073.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
CC Sequence=KBJ28301.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
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DR EMBL; AL123456; CCP46073.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP003248; AFN51259.1; ALT_INIT; Genomic_DNA.
DR EMBL; JLDD01000039; KBJ28301.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_217771.1; NC_000962.3.
DR AlphaFoldDB; O05897; -.
DR SMR; O05897; -.
DR STRING; 83332.Rv3254; -.
DR PaxDb; O05897; -.
DR PRIDE; O05897; -.
DR DNASU; 887237; -.
DR GeneID; 887237; -.
DR KEGG; mtu:Rv3254; -.
DR KEGG; mtv:RVBD_3254; -.
DR PATRIC; fig|83332.111.peg.3633; -.
DR TubercuList; Rv3254; -.
DR eggNOG; COG0654; Bacteria.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome.
FT PROPEP 1..4
FT /evidence="ECO:0000269|PubMed:34915127"
FT /id="PRO_0000455444"
FT CHAIN 5..474
FT /note="Protein Rv3254"
FT /id="PRO_0000432521"
SQ SEQUENCE 474 AA; 52783 MW; F9D5DD1EF902244E CRC64;
MTGRVGNPKD HAVVIGASIA GLCAARVLSD FYSTVTVFER DELPEAPANR ATVPQDRHLH
MLMARGAQEF DSLFPGLLHD MVAAGVPMLE NRPDCIYLGA AGHVLGTGHT LRKEFTAYVP
SRPHLEWQLR RRVLQLSNVQ IVRRLVTEPQ FERRQQRVVG VLLDSPGSGQ DREREEFIAA
DLVVDAAGRG TRLPVWLTQW GYRRPAEDTV DIGISYASHQ FRIPDGLIAE KVVVAGASHD
QSLGLGMLCY EDGTWVLTTF GVADAKPPPT FDEMRALADK LLPARFTAAL AQAQPIGCPA
FHAFPASRWR RYDKLERFPR GIVPFGDAVA SFNPTFGQGM TMTSLQAGHL RRALKARNSA
MKGDLAAELN RATAKTTYPV WMMNAIGDIS FHHATAEPLP RWWRPAGSLF DQFLGAAETD
PVLAEWFLRR FSLLDSLYMV PSVPIIGRAI AHNLRLWLKE QRERRQPVTT RRSP
