ID   Y325_THEMA              Reviewed;         251 AA.
AC   Q9WYG0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Uncharacterized oxidoreductase TM_0325;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=TM_0325;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD35412.1; -; Genomic_DNA.
DR   PIR; G72389; G72389.
DR   RefSeq; NP_228136.1; NC_000853.1.
DR   RefSeq; WP_004083078.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WYG0; -.
DR   SMR; Q9WYG0; -.
DR   STRING; 243274.THEMA_03100; -.
DR   EnsemblBacteria; AAD35412; AAD35412; TM_0325.
DR   KEGG; tma:TM0325; -.
DR   eggNOG; COG1028; Bacteria.
DR   InParanoid; Q9WYG0; -.
DR   OMA; GICEFKE; -.
DR   OrthoDB; 1356861at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..251
FT                   /note="Uncharacterized oxidoreductase TM_0325"
FT                   /id="PRO_0000054867"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         10..34
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  26635 MW;  61C736A0F13564A5 CRC64;
     MNFQGKVVLI TGAGSGIGKK AAVMFAERGA KVAINDISEE KGKETVELIK SMGGEAAFIF
     GDVAKDAEQI VKKTVETFGR LDILVNNAGI VPYGNIEETS EEDFDKTMAV NVKGPFLLSK
     YAVEQMKKQG GGVIVNVSSE AGLIGIPRRC VYSVSKAALL GLTRSLAVDY VDYGIRVNAV
     CPGTTQSEGL MARVKASPNP EELLKKMTSR IPMKRLGKEE EIAFAILFAA CDEAGFMTGS
     IINIDGGSTA V