ID   Y326_METJA              Reviewed;         436 AA.
AC   Q57772;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Putative permease MJ0326;
GN   OrderedLocusNames=MJ0326;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000305}.
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DR   EMBL; L77117; AAB98314.1; -; Genomic_DNA.
DR   PIR; F64340; F64340.
DR   AlphaFoldDB; Q57772; -.
DR   STRING; 243232.MJ_0326; -.
DR   EnsemblBacteria; AAB98314; AAB98314; MJ_0326.
DR   KEGG; mja:MJ_0326; -.
DR   eggNOG; arCOG02807; Archaea.
DR   HOGENOM; CLU_024508_0_1_2; -.
DR   InParanoid; Q57772; -.
DR   OMA; RKGSYFF; -.
DR   PhylomeDB; Q57772; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015853; P:adenine transport; IBA:GO_Central.
DR   GO; GO:0015854; P:guanine transport; IBA:GO_Central.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR026033; Azg-like_bact_archaea.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; PTHR43337; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PIRSF; PIRSF005353; PbuG; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..436
FT                   /note="Putative permease MJ0326"
FT                   /id="PRO_0000106795"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   436 AA;  46723 MW;  409B4075F6D70891 CRC64;
     MIMKFVEKYF EFEKYGTNLK VETLAGITTF MTMAYIIFVN PQILSTAGMD FGAVMVATCI
     ASAIATLVMG LYARYPFALA PGMGLNAYFT YGVCLGMGID WRVALGAVFI SGVLFIILTL
     TKIRTWIFNV IPNAIKYGTA VGIGLFIAFI GLKSAGIIVS SKATLVTLGN LMEPSTLLAL
     FGIFLTSILV SRNVIGAILI GIIVTSLIGM ILGISPFPEG IFSMPPSIAP TFLQLDIMGA
     LNLGLLTIVL AFFFVDMFDT LGTLSALASQ AGYLDKDGKL PRVEKALMAD ATGTVVGSLL
     GTSTVTTYIE SASGIALGGR TGFVSVVVAM LFLLSLFFYP VVKAIPPYAT AAALVIVGAL
     MMRSVKYIDF DDYTEAIPAF ITLLTIPLTF SIATGLALGF ITYPILKVFT GRWKEVHWLV
     YVLAVIFALR FVYLSG