ID   Y326_THEMA              Reviewed;         280 AA.
AC   Q9WYG1;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator TM_0326;
GN   OrderedLocusNames=TM_0326;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
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DR   EMBL; AE000512; AAD35413.1; -; Genomic_DNA.
DR   PIR; H72389; H72389.
DR   RefSeq; NP_228137.1; NC_000853.1.
DR   RefSeq; WP_004083079.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WYG1; -.
DR   SMR; Q9WYG1; -.
DR   STRING; 243274.THEMA_03095; -.
DR   EnsemblBacteria; AAD35413; AAD35413; TM_0326.
DR   KEGG; tma:TM0326; -.
DR   eggNOG; COG1737; Bacteria.
DR   InParanoid; Q9WYG1; -.
DR   OMA; VPFIHRS; -.
DR   OrthoDB; 992687at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd05013; SIS_RpiR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR000281; HTH_RpiR.
DR   InterPro; IPR035472; RpiR-like_SIS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF01418; HTH_6; 1.
DR   Pfam; PF01380; SIS; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51071; HTH_RPIR; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..280
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   TM_0326"
FT                   /id="PRO_0000068632"
FT   DOMAIN          1..78
FT                   /note="HTH rpiR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT   DOMAIN          123..263
FT                   /note="SIS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DNA_BIND        37..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
SQ   SEQUENCE   280 AA;  31117 MW;  AA7D3C0212BCBD30 CRC64;
     MDVIQRIKEK YDEFTNAEKK IADTILSDPK GIIESSISDL SEKAGVKSEA SVVKFYKKLG
     LNSFQQFKVL LAQSISRAPL EIVYEDVSSE DDTKTITEKI FKATVRAILD TLNWLDIDSI
     ERTVDLFKNA QRIIFIGFAA SAAVAFDAFH KFTRIGKNCL FSNDEHIIAA ILATASPSDL
     LVAISHTGET ISVVNFAKKA KEMKMPVVTI TGNRKSTLAK YSDVVLATNT KETKIRTDAM
     TSRIVQLVIL DTIYTLLAAR DPRAIENLNK SRLAVSELKY