ID   Y3284_MYCTU             Reviewed;         143 AA.
AC   P9WGC3; L0TCC5; P67123; P96889;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Uncharacterized SufE-like protein Rv3284;
GN   OrderedLocusNames=Rv3284; ORFNames=MTCY71.24;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the SufE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46103.1; -; Genomic_DNA.
DR   PIR; E70980; E70980.
DR   RefSeq; NP_217801.1; NC_000962.3.
DR   RefSeq; WP_003417152.1; NZ_NVQJ01000003.1.
DR   AlphaFoldDB; P9WGC3; -.
DR   SMR; P9WGC3; -.
DR   STRING; 83332.Rv3284; -.
DR   iPTMnet; P9WGC3; -.
DR   PaxDb; P9WGC3; -.
DR   GeneID; 45427280; -.
DR   GeneID; 887966; -.
DR   KEGG; mtu:Rv3284; -.
DR   TubercuList; Rv3284; -.
DR   eggNOG; COG2166; Bacteria.
DR   OMA; EQVVECQ; -.
DR   PhylomeDB; P9WGC3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   InterPro; IPR003808; Fe-S_metab-assoc_dom.
DR   PANTHER; PTHR43597; PTHR43597; 1.
DR   Pfam; PF02657; SufE; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:21969609"
FT   CHAIN           2..143
FT                   /note="Uncharacterized SufE-like protein Rv3284"
FT                   /id="PRO_0000202140"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0007744|PubMed:21969609"
SQ   SEQUENCE   143 AA;  15395 MW;  C05E186CD3D2081D CRC64;
     MTAPASLPAP LAEVVSDFAE VQGQDKLRLL LEFANELPAL PSHLAESAME PVPECQSPLF
     LHVDASDPNR VRLHFSAPAE APTTRGFASI LAAGLDEQPA ADILAVPEDF YTELGLAALI
     SPLRLRGMSA MLARIKRRLR EAD