Y3295_ARATH
ID Y3295_ARATH Reviewed; 556 AA.
AC Q9LF97; Q8L7L7;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=CBS domain-containing protein CBSCBSPB3;
GN Name=CBSCBSPB3; OrderedLocusNames=At3g52950; ORFNames=F8J2_120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-556.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19400948; DOI=10.1186/1471-2164-10-200;
RA Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.;
RT "Genome wide expression analysis of CBS domain containing proteins in
RT Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their
RT developmental and stress regulation.";
RL BMC Genomics 10:200-200(2009).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM91587.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL132969; CAB86899.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79016.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79017.1; -; Genomic_DNA.
DR EMBL; AY128384; AAM91587.1; ALT_INIT; mRNA.
DR EMBL; BT000120; AAN15439.1; -; mRNA.
DR PIR; T47552; T47552.
DR RefSeq; NP_001190074.1; NM_001203145.1.
DR RefSeq; NP_190863.3; NM_115155.5.
DR AlphaFoldDB; Q9LF97; -.
DR SMR; Q9LF97; -.
DR STRING; 3702.AT3G52950.1; -.
DR iPTMnet; Q9LF97; -.
DR PaxDb; Q9LF97; -.
DR PRIDE; Q9LF97; -.
DR ProteomicsDB; 234607; -.
DR EnsemblPlants; AT3G52950.1; AT3G52950.1; AT3G52950.
DR EnsemblPlants; AT3G52950.2; AT3G52950.2; AT3G52950.
DR GeneID; 824461; -.
DR Gramene; AT3G52950.1; AT3G52950.1; AT3G52950.
DR Gramene; AT3G52950.2; AT3G52950.2; AT3G52950.
DR KEGG; ath:AT3G52950; -.
DR Araport; AT3G52950; -.
DR TAIR; locus:2085166; AT3G52950.
DR eggNOG; ENOG502QVK2; Eukaryota.
DR HOGENOM; CLU_009026_3_0_1; -.
DR InParanoid; Q9LF97; -.
DR OMA; ERQWGAN; -.
DR OrthoDB; 490251at2759; -.
DR PhylomeDB; Q9LF97; -.
DR PRO; PR:Q9LF97; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LF97; baseline and differential.
DR Genevisible; Q9LF97; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR034896; CBSCBSPB.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13780:SF116; PTHR13780:SF116; 1.
DR Pfam; PF00571; CBS; 4.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00116; CBS; 4.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54631; SSF54631; 2.
DR PROSITE; PS51371; CBS; 4.
DR PROSITE; PS51745; PB1; 1.
PE 1: Evidence at protein level;
KW Acetylation; CBS domain; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..556
FT /note="CBS domain-containing protein CBSCBSPB3"
FT /id="PRO_0000412229"
FT TRANSMEM 527..549
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 68..127
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 134..189
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 235..294
FT /note="CBS 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 302..360
FT /note="CBS 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 414..502
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22223895"
SQ SEQUENCE 556 AA; 60026 MW; C193B889577DAE01 CRC64;
MSTQATGPSS TSGRRSNSTV RRGPPPSKKP VQSENGSVNG NTSKPNSPPP QPQSQAPSNG
ERTVKKLRLS KALTIPEGTT VFDACRRMAA RRVDACLLTD SSALLSGIVT DKDVATRVIA
EGLRPDQTLV SKVMTRNPIF VTSDSLALEA LQKMVQGKFR HLPVVENGEV IALLDITKCL
YDAISRMEKA AEQGSALAAA VEGVEKQWGS GYSAPYAFIE TLRERMFKPA LSTIITDNSK
VALVAPSDPV SVAAKRMRDL RVNSVIISTG NKISGILTSK DILMRVVAQN LSPELTLVEK
VMTPNPECAS LETTILDALH TMHDGKFLHL PIIDKDGSAA ACVDVLQITH AAISMVENSS
GAVNDMANTM MQKFWDSALA LEPPDDSDTQ SEMSAMMHHS DIGKLSSYPS LGLGNSFSFK
FEDLKGRVHR FTSGAENLEE LMGIVMQRIG SDNNNVEQRP QIIYEDDEGD KVLITSDSDL
VGAVTLARST GQKVLRLHLD FTESTRSLSS ETTQLKKGDS RDRGSGWVSW RGGVVVTGAV
VLTSIAIVVY LKRSKN
