ID   Y3311_PSEAE             Reviewed;         783 AA.
AC   Q9HYT3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Uncharacterized signaling protein PA3311;
GN   OrderedLocusNames=PA3311;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00244}.
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DR   EMBL; AE004091; AAG06699.1; -; Genomic_DNA.
DR   PIR; B83232; B83232.
DR   RefSeq; NP_252001.1; NC_002516.2.
DR   RefSeq; WP_010895656.1; NZ_QZGE01000017.1.
DR   AlphaFoldDB; Q9HYT3; -.
DR   SMR; Q9HYT3; -.
DR   STRING; 287.DR97_4616; -.
DR   PaxDb; Q9HYT3; -.
DR   PRIDE; Q9HYT3; -.
DR   EnsemblBacteria; AAG06699; AAG06699; PA3311.
DR   GeneID; 882476; -.
DR   KEGG; pae:PA3311; -.
DR   PATRIC; fig|208964.12.peg.3468; -.
DR   PseudoCAP; PA3311; -.
DR   HOGENOM; CLU_000445_70_49_6; -.
DR   InParanoid; Q9HYT3; -.
DR   OMA; RMVMTTS; -.
DR   PhylomeDB; Q9HYT3; -.
DR   BioCyc; PAER208964:G1FZ6-3375-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071111; F:cyclic-guanylate-specific phosphodiesterase activity; IDA:PseudoCAP.
DR   GO; GO:0071732; P:cellular response to nitric oxide; IMP:PseudoCAP.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.20.20.450; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR005330; MHYT_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF03707; MHYT; 3.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; SSF141868; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   TIGRFAMs; TIGR00254; GGDEF; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50924; MHYT; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..783
FT                   /note="Uncharacterized signaling protein PA3311"
FT                   /id="PRO_0000170475"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   DOMAIN          81..274
FT                   /note="MHYT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00244"
FT   DOMAIN          375..507
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00095"
FT   DOMAIN          516..770
FT                   /note="EAL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00074"
SQ   SEQUENCE   783 AA;  86817 MW;  7D881B379356430F CRC64;
     MPFLPGKMPK PAVCRRPATS FHADLAGGSR YLYWKHNATP SPHPRRPRVF RVQGDTAMDW
     QGLRFLGESP VDGYVLQNCT YSPSLVALAF LVACLAGYTA LDMVERVGNS LSHPRLWQWI
     GAFCLGSGIW ATHFVAMLAF HAPIALRYDL PITGLSLLIA VAASYLTMYM TARPRFGLLP
     CLLAACCIGL GIAAMHYTGM AAMRSVATQY YQPSLFALSV LIAIGAAFTA LAAVPYLRGR
     RSARYRYMKL IASLLLAGAI AAMHFTGMAA LVLSVPAGTP LELQASADSL RLGWLTGVLA
     SAIAACGIWA AWSEKQRERR LSENSRVNAL LNQLDHAHAS LRQMARYDSL TGLQNRTAFN
     EVFVQHLENC RLRGKGLAVM FLDLDHFKRI NDSLGHDSGD QLLKIVSERI RSVLRDSDVV
     ARFAGDEFCV LADLTQDHEA HILSQRLMQK MKEPIALDGR TLVMTASVGV SLYPNDGEQC
     EELLKNAGLA LHQSKACGRN NAQFFSRQLL VRATQELQME EELRQALRDD QLELHYQPIL
     ALADGEVHQL EALVRWRHPT QGLLGPDRFI GLAEANGMID QLDDWVLRRA CRDLRSLHLA
     GHERLRVAVN CCASNLGRAS LVDEVRHALE QAGLAACFLE LEVTEDALMY NIDQTIPLLE
     RLRELGVSLS IDDFGTGYSS LAYLRRLPLD ALKVDRSFIM DIPASQRDME IAQAIIAMAQ
     KLHLKVVAEG VETPQQLAFL RENHCELVQG YLFSRPLPLA ALEEFLRAYR FDAAPPLRSL
     NQA