ID   Y3351_ARATH             Reviewed;         508 AA.
AC   Q9SRQ5; Q1PET5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=BTB/POZ domain-containing protein At3g03510;
GN   OrderedLocusNames=At3g03510; ORFNames=T21P5.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-508.
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00982}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF01584.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AEE73952.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC009895; AAF01584.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE73952.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DQ446632; ABE65915.1; -; mRNA.
DR   RefSeq; NP_187001.2; NM_111222.2.
DR   AlphaFoldDB; Q9SRQ5; -.
DR   PaxDb; Q9SRQ5; -.
DR   PRIDE; Q9SRQ5; -.
DR   ProteomicsDB; 242582; -.
DR   EnsemblPlants; AT3G03510.1; AT3G03510.1; AT3G03510.
DR   GeneID; 821246; -.
DR   Gramene; AT3G03510.1; AT3G03510.1; AT3G03510.
DR   KEGG; ath:AT3G03510; -.
DR   Araport; AT3G03510; -.
DR   eggNOG; ENOG502QQV1; Eukaryota.
DR   HOGENOM; CLU_005994_6_2_1; -.
DR   InParanoid; Q9SRQ5; -.
DR   OrthoDB; 509550at2759; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9SRQ5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SRQ5; baseline and differential.
DR   Genevisible; Q9SRQ5; AT.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR043454; NPH3/RPT2-like.
DR   InterPro; IPR027356; NPH3_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR32370; PTHR32370; 2.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF03000; NPH3; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS51649; NPH3; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..508
FT                   /note="BTB/POZ domain-containing protein At3g03510"
FT                   /id="PRO_0000409572"
FT   DOMAIN          11..77
FT                   /note="BTB"
FT   DOMAIN          156..414
FT                   /note="NPH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT   MOD_RES         355
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ   SEQUENCE   508 AA;  58142 MW;  BE715F1BF4053309 CRC64;
     MLIVCRNSKS QDLDLYVKGV HFHLNKTLAK RSAKVTTLLE SNKLHELRWI IRDMDINPSI
     FHLVTRFCYG YKIELSADNI VSVLCIAYYL EMSDDHSSNN LLNKAVTFLE QRVLMSWSET
     VKALCICSDK ILDKLANVGL IEVFLDSLIE KALNDTRLLQ DLITLPLRLY EPLILEVSKH
     NVSLENLVAS VCNYANRWVF EKDSGDGSVS RNKREGIEAV ERLLPHQRGT ISSGFLFKSL
     KESIFLGACS DCRKGFEVRI SNQLDMARAK DLQILSPTED GSYDIELLKT ILKSFYSNDS
     VPDLSRFVSV ARMLEEFLLE AAASDAGLRV GTFKELAEIA VAASCDVLSY SDGIYRAIDV
     YLERHRDLIE SEKMEACRFL HCKKLSPEAC EHASKNEKLP LRIVMQVLFV SQMQIRDKVA
     REMKGVVERT ENQVDEVESM SKKLLKLEIE PDYMKKRKIE NLECVVHCEK KKTSVWREVK
     RKFGCMTSST MDACSCHIKK RKTYHSYK