ID   Y3376_MYCTU             Reviewed;         217 AA.
AC   P9WMS5; F2GEC2; L0TDY8; O50405; Q7D5L7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Phosphatase Rv3376;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=Rv3376;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION AS A PHOSPHATASE, AND SUBSTRATE SPECIFICITY.
RX   PubMed=21228491; DOI=10.1271/bbb.100570;
RA   Nakano C., Ootsuka T., Takayama K., Mitsui T., Sato T., Hoshino T.;
RT   "Characterization of the Rv3378c gene product, a new diterpene synthase for
RT   producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from
RT   the Mycobacterium tuberculosis H37Rv genome.";
RL   Biosci. Biotechnol. Biochem. 75:75-81(2011).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Able to hydrolyze geranyl diphosphate (GPP), farnesyl
CC       diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) to respectively
CC       yield geraniol, farnesol and geranylgeraniol.
CC       {ECO:0000269|PubMed:21228491}.
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP46197.1; -; Genomic_DNA.
DR   PIR; G70972; G70972.
DR   RefSeq; NP_217893.1; NC_000962.3.
DR   RefSeq; WP_003417903.1; NZ_NVQJ01000052.1.
DR   AlphaFoldDB; P9WMS5; -.
DR   SMR; P9WMS5; -.
DR   STRING; 83332.Rv3376; -.
DR   PaxDb; P9WMS5; -.
DR   PRIDE; P9WMS5; -.
DR   DNASU; 888066; -.
DR   GeneID; 888066; -.
DR   KEGG; mtu:Rv3376; -.
DR   TubercuList; Rv3376; -.
DR   eggNOG; COG1011; Bacteria.
DR   OMA; ELLPWRY; -.
DR   PhylomeDB; P9WMS5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016791; F:phosphatase activity; IDA:UniProtKB.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR023214; HAD_sf.
DR   PRINTS; PR00413; HADHALOGNASE.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01549; HAD-SF-IA-v1; 1.
DR   TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..217
FT                   /note="Phosphatase Rv3376"
FT                   /id="PRO_0000416458"
FT   ACT_SITE        9
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  23664 MW;  0AFCDC61F2BD0156 CRC64;
     MSISAVVFDR DGVLTSFDWT RAEEDVRRIT GLPLEEIERR WGGWLNGLTI DDAFVETQPI
     SEFLSSLARE LELGSKARDE LVRLDYMAFA QGYPDARPAL EEARRRGLKV GVLTNNSLLV
     SARSLLQCAA LHDLVDVVLS SQMIGAAKPD PRAYQAIAEA LGVSTTSCLF FDDIADWVEG
     ARCAGMRAYL VDRSGQTRDG VVRDLSSLGA ILDGAGP