ID   Y337_THEMA              Reviewed;         567 AA.
AC   Q9WYH2;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=UPF0313 protein TM_0337 {ECO:0000255|HAMAP-Rule:MF_01251};
GN   OrderedLocusNames=TM_0337;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000255|HAMAP-Rule:MF_01251};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01251}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD35424.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000512; AAD35424.1; ALT_INIT; Genomic_DNA.
DR   PIR; C72391; C72391.
DR   RefSeq; NP_228148.1; NC_000853.1.
DR   RefSeq; WP_004083105.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WYH2; -.
DR   STRING; 243274.THEMA_03035; -.
DR   PRIDE; Q9WYH2; -.
DR   EnsemblBacteria; AAD35424; AAD35424; TM_0337.
DR   KEGG; tma:TM0337; -.
DR   PATRIC; fig|243274.5.peg.342; -.
DR   eggNOG; COG1032; Bacteria.
DR   InParanoid; Q9WYH2; -.
DR   OMA; TCMYYTG; -.
DR   OrthoDB; 229299at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..567
FT                   /note="UPF0313 protein TM_0337"
FT                   /id="PRO_0000076397"
FT   DOMAIN          288..560
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   BINDING         303
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         307
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         310
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ   SEQUENCE   567 AA;  64967 MW;  8ED2B2F52606555F CRC64;
     MFLPTTREEM RKLGWKELDI ILVTGDAYVD HPSFGVAFIG HYLVSHGFKV GIIAQPDWRT
     EKDITRLGRP RLFFGVTAGN VDSMVANYTA SKKKRKTDDY TPGGIGGKRP DRATIVYTNL
     IKRFFPEVPV VLGGLEASLR RFAHYDWWSD RVRKSVLVDS KADLLVYGMG EKAVLGIAQI
     LSRTGDIEKC KSIRGVVWWA SQKPEEGIEL PSYDEISENP EKYAEALKLQ TWYTDPYKNI
     PIYQRQDTRY VVQNPPQPPL SQEELDRLYL LPFEREVHPF YAKMGKVKAI ETVKFSITAV
     RGCFGNCSFC ALTQHQTTHV SYRSKDSILE EVRILTKKKD FKGTITDVGG PTANLYGSGC
     SIRETKGQCQ KFCLYPIVCK VVRPNHDEFI SLLESIRQIP GVRNVFVSSG IRHDFVFAEK
     DPDVFIRELV KYTPGQLKLA PEHAHPKVLS LMRKPPVELF LEFKKRFETL AKKMGKRKYV
     IGYFIVGHPG EGWRENNYLR DFILKHLGYF PQQIQIFTPT PGTVSTAMYY SGVDPFTGEK
     VHVERSLKVR NKMKENVLFK KKGREKR