ID   Y3385_MYCPA             Reviewed;         304 AA.
AC   Q73UI3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_3385;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_3385;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS05935.1; -; Genomic_DNA.
DR   RefSeq; WP_003874539.1; NC_002944.2.
DR   AlphaFoldDB; Q73UI3; -.
DR   SMR; Q73UI3; -.
DR   STRING; 262316.MAP_3385; -.
DR   PRIDE; Q73UI3; -.
DR   EnsemblBacteria; AAS05935; AAS05935; MAP_3385.
DR   KEGG; mpa:MAP_3385; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; GMQRMTD; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..304
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_3385"
FT                   /id="PRO_0000361179"
FT   BINDING         129
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         158..159
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   304 AA;  32376 MW;  803CEACA7E0E26C3 CRC64;
     MARTDDDTWD LATSVGATAT MVAAGRARAT RDGLIDDPFA EPLVRAVGVD FFTRWAAGEL
     DAADVDVPGA AWGMQRMTDM LTARTRYIDA FFAEAGAAGI RQVVILASGL DARAYRLPWP
     AGTTVFEIDQ PRVLEFKAAT IAQLGAEPTA PVRAVAVDLR HDWPSALRQA GFDVGRPAAW
     AAEGLLGFLP PQAQDRLLDN VTALSADGSQ LVAEVFANTG ASGDALNAAG EKWRRHGLDV
     ALDDLGFPGE RNDPASYLQQ LGWQPVRTPL NQMLANNGLP LQSTEPGAPF AQNYYCTAVL
     NKAG