ID   Y3399_MYCTU             Reviewed;         348 AA.
AC   P9WFH1; L0TFA0; Q50726;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 2.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3399;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv3399; ORFNames=MTCY78.29c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250|UniProtKB:Q9CCZ4}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP46221.1; -; Genomic_DNA.
DR   PIR; D70735; D70735.
DR   RefSeq; NP_217916.1; NC_000962.3.
DR   RefSeq; WP_010886169.1; NC_000962.3.
DR   AlphaFoldDB; P9WFH1; -.
DR   SMR; P9WFH1; -.
DR   STRING; 83332.Rv3399; -.
DR   PaxDb; P9WFH1; -.
DR   GeneID; 887938; -.
DR   KEGG; mtu:Rv3399; -.
DR   PATRIC; fig|83332.12.peg.3796; -.
DR   TubercuList; Rv3399; -.
DR   eggNOG; COG3315; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..348
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv3399"
FT                   /id="PRO_0000104118"
FT   BINDING         171
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CCZ4"
FT   BINDING         200..201
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CCZ4"
SQ   SEQUENCE   348 AA;  38140 MW;  8C06D9F9BEFEBFBD CRC64;
     MARPMGKLPS NTRKCAQCAM AEALLEIAGQ TINQKDLGRS GRMTRTDNDT WDLASSVGAT
     ATMIATARAL ASRAENPLIN DPFAEPLVRA VGIDLFTRLA SGELRLEDIG DHATGGRWMI
     DNIAIRTKFY DDFFGDATTA GIRQVVILAA GLDTRAYRLP WPPGTVVYEI DQPAVIKFKT
     RALANLNAEP NAERHAVAVD LRNDWPTALK NAGFDPARPT AFSAEGLLSY LPPQGQDRLL
     DAITALSAPD SRLATQSPLV LDLAEEDEKK MRMKSAAEAW RERGFDLDLT ELIYFDQRND
     VADYLAGSGW QVTTSTGKEL FAAQGLPPFA DDHITRFADR RYISAVLK