ID   Y3401_MYCTO             Reviewed;         786 AA.
AC   P9WN12; L0TCF3; Q50724;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Uncharacterized glycosyl hydrolase MT3509;
DE            EC=3.2.1.-;
GN   OrderedLocusNames=MT3509;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47846.1; -; Genomic_DNA.
DR   PIR; F70735; F70735.
DR   RefSeq; WP_003900047.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WN12; -.
DR   SMR; P9WN12; -.
DR   CAZy; GH65; Glycoside Hydrolase Family 65.
DR   EnsemblBacteria; AAK47846; AAK47846; MT3509.
DR   GeneID; 45427397; -.
DR   KEGG; mtc:MT3509; -.
DR   PATRIC; fig|83331.31.peg.3766; -.
DR   HOGENOM; CLU_006285_2_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProt.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 2.70.98.40; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR005194; Glyco_hydro_65_C.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   InterPro; IPR005196; Glyco_hydro_65_N.
DR   InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR   InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR   Pfam; PF03633; Glyco_hydro_65C; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 1.
DR   Pfam; PF03636; Glyco_hydro_65N; 1.
DR   PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase.
FT   CHAIN           1..786
FT                   /note="Uncharacterized glycosyl hydrolase MT3509"
FT                   /id="PRO_0000427207"
FT   REGION          762..786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        488
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
FT   BINDING         361..362
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
FT   BINDING         590..591
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
SQ   SEQUENCE   786 AA;  87316 MW;  73CB5E78DAD10AE6 CRC64;
     MITEDAFPVE PWQVRETKLN LNLLAQSESL FALSNGHIGL RGNLDEGEPF GLPGTYLNSF
     YEIRPLPYAE AGYGYPEAGQ TVVDVTNGKI FRLLVGDEPF DVRYGELISH ERILDLRAGT
     LTRRAHWRSP AGKQVKVTST RLVSLAHRSV AAIEYVVEAI EEFVRVTVQS ELVTNEDVPE
     TSADPRVSAI LDRPLQAVEH ERTERGALLM HRTRASALMM AAGMEHEVEV PGRVEITTDA
     RPDLARTTVI CGLRPGQKLR IVKYLAYGWS SLRSRPALRD QAAGALHGAR YSGWQGLLDA
     QRAYLDDFWD SADVEVEGDP ECQQAVRFGL FHLLQASARA ERRAIPSKGL TGTGYDGHAF
     WDTEGFVLPV LTYTAPHAVA DALRWRASTL DLAKERAAEL GLEGAAFPWR TIRGQESSAY
     WPAGTAAWHI NADIAMAFER YRIVTGDGSL EEECGLAVLI ETARLWLSLG HHDRHGVWHL
     DGVTGPDEYT AVVRDNVFTN LMAAHNLHTA ADACLRHPEA AEAMGVTTEE MAAWRDAADA
     ANIPYDEELG VHQQCEGFTT LAEWDFEANT TYPLLLHEAY VRLYPAQVIK QADLVLAMQW
     QSHAFTPEQK ARNVDYYERR MVRDSSLSAC TQAVMCAEVG HLELAHDYAY EAALIDLRDL
     HRNTRDGLHM ASLAGAWTAL VVGFGGLRDD EGILSIDPQL PDGISRLRFR LRWRGFRLIV
     DANHTDVTFI LGDGPGTQLT MRHAGQDLTL HTDTPSTIAV RTRKPLLPPP PQPPGREPVH
     RRALAR