ID   Y3401_MYCTU             Reviewed;         786 AA.
AC   P9WN13; L0TCF3; Q50724;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Uncharacterized glycosyl hydrolase Rv3401;
DE            EC=3.2.1.-;
GN   OrderedLocusNames=Rv3401; ORFNames=MTCY78.27c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46223.1; -; Genomic_DNA.
DR   PIR; F70735; F70735.
DR   RefSeq; NP_217918.1; NC_000962.3.
DR   RefSeq; WP_003900047.1; NZ_NVQJ01000027.1.
DR   AlphaFoldDB; P9WN13; -.
DR   SMR; P9WN13; -.
DR   STRING; 83332.Rv3401; -.
DR   PaxDb; P9WN13; -.
DR   DNASU; 887928; -.
DR   GeneID; 45427397; -.
DR   GeneID; 887928; -.
DR   KEGG; mtu:Rv3401; -.
DR   TubercuList; Rv3401; -.
DR   eggNOG; COG1554; Bacteria.
DR   OMA; EAYCIPF; -.
DR   PhylomeDB; P9WN13; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProt.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IBA:GO_Central.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 2.70.98.40; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR005194; Glyco_hydro_65_C.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   InterPro; IPR005196; Glyco_hydro_65_N.
DR   InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR   InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR   Pfam; PF03633; Glyco_hydro_65C; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 1.
DR   Pfam; PF03636; Glyco_hydro_65N; 1.
DR   PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
PE   1: Evidence at protein level;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..786
FT                   /note="Uncharacterized glycosyl hydrolase Rv3401"
FT                   /id="PRO_0000108021"
FT   REGION          762..786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        488
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
FT   BINDING         361..362
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
FT   BINDING         590..591
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
SQ   SEQUENCE   786 AA;  87316 MW;  73CB5E78DAD10AE6 CRC64;
     MITEDAFPVE PWQVRETKLN LNLLAQSESL FALSNGHIGL RGNLDEGEPF GLPGTYLNSF
     YEIRPLPYAE AGYGYPEAGQ TVVDVTNGKI FRLLVGDEPF DVRYGELISH ERILDLRAGT
     LTRRAHWRSP AGKQVKVTST RLVSLAHRSV AAIEYVVEAI EEFVRVTVQS ELVTNEDVPE
     TSADPRVSAI LDRPLQAVEH ERTERGALLM HRTRASALMM AAGMEHEVEV PGRVEITTDA
     RPDLARTTVI CGLRPGQKLR IVKYLAYGWS SLRSRPALRD QAAGALHGAR YSGWQGLLDA
     QRAYLDDFWD SADVEVEGDP ECQQAVRFGL FHLLQASARA ERRAIPSKGL TGTGYDGHAF
     WDTEGFVLPV LTYTAPHAVA DALRWRASTL DLAKERAAEL GLEGAAFPWR TIRGQESSAY
     WPAGTAAWHI NADIAMAFER YRIVTGDGSL EEECGLAVLI ETARLWLSLG HHDRHGVWHL
     DGVTGPDEYT AVVRDNVFTN LMAAHNLHTA ADACLRHPEA AEAMGVTTEE MAAWRDAADA
     ANIPYDEELG VHQQCEGFTT LAEWDFEANT TYPLLLHEAY VRLYPAQVIK QADLVLAMQW
     QSHAFTPEQK ARNVDYYERR MVRDSSLSAC TQAVMCAEVG HLELAHDYAY EAALIDLRDL
     HRNTRDGLHM ASLAGAWTAL VVGFGGLRDD EGILSIDPQL PDGISRLRFR LRWRGFRLIV
     DANHTDVTFI LGDGPGTQLT MRHAGQDLTL HTDTPSTIAV RTRKPLLPPP PQPPGREPVH
     RRALAR