ID   Y3402_MYCTU             Reviewed;         412 AA.
AC   P9WGJ7; L0TCN5; Q50723;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Protein Rv3402c;
GN   OrderedLocusNames=Rv3402c; ORFNames=MTCY78.26;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11722747; DOI=10.1046/j.1365-2958.2001.02684.x;
RA   Gold B., Rodriguez G.M., Marras S.A.E., Pentecost M., Smith I.;
RT   "The Mycobacterium tuberculosis IdeR is a dual functional regulator that
RT   controls transcription of genes involved in iron acquisition, iron storage
RT   and survival in macrophages.";
RL   Mol. Microbiol. 42:851-865(2001).
CC   -!- INDUCTION: Transcriptionally repressed by IdeR and iron. Induced during
CC       infection of human THP-1 macrophages. {ECO:0000269|PubMed:11722747}.
CC   -!- SIMILARITY: Belongs to the DegT/DnrJ/EryC1 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46224.1; -; Genomic_DNA.
DR   PIR; G70735; G70735.
DR   RefSeq; NP_217919.1; NC_000962.3.
DR   RefSeq; WP_003900048.1; NZ_NVQJ01000027.1.
DR   AlphaFoldDB; P9WGJ7; -.
DR   SMR; P9WGJ7; -.
DR   STRING; 83332.Rv3402c; -.
DR   PaxDb; P9WGJ7; -.
DR   DNASU; 887910; -.
DR   GeneID; 887910; -.
DR   KEGG; mtu:Rv3402c; -.
DR   TubercuList; Rv3402c; -.
DR   eggNOG; COG0399; Bacteria.
DR   OMA; RFWATQA; -.
DR   PhylomeDB; P9WGJ7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0010106; P:cellular response to iron ion starvation; IEP:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IEP:MTBBASE.
DR   CDD; cd00616; AHBA_syn; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR000653; DegT/StrS_aminotransferase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR30244; PTHR30244; 1.
DR   Pfam; PF01041; DegT_DnrJ_EryC1; 1.
DR   PIRSF; PIRSF000390; PLP_StrS; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   2: Evidence at transcript level;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..412
FT                   /note="Protein Rv3402c"
FT                   /id="PRO_0000104122"
FT   MOD_RES         227
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   412 AA;  44897 MW;  D0A76046EF800FF2 CRC64;
     MKIRTLSGSV LEPPSAVRAT PGTSMLKLEP GGSTIPKIPF IRPSFPGPAE LAEDFVQIAQ
     ANWYTNFGPN ERRFARALRD YLGPHLHVAT LANGTLALLA ALHVSFGAGT RDRYLLMPSF
     TFVGVAQAAL WTGYRPWFID IDANTWQPCV HSARAVIERF RDRIAGILLA NVFGVGNPQI
     SVWEELAAEW ELPIVLDSAA GFGSTYADGE RLGGRGACEI FSFHATKPFA VGEGGALVSR
     DPRLVEHAYK FQNFGLVQTR ESIQLGMNGK LSEISAAIGL RQLVGLDRRL ASRRKVLECY
     RTGMADAGVR FQDNANVASL CFASACCTSA DHKAAVLGSL RRHAIEARDY YNPPQHRHPY
     FVTNAELVES TDLAVTADIC SRIVSLPVHD HMAPDDVARV VAAVQEAEVR GE