ID   Y3403_MYCTU             Reviewed;         533 AA.
AC   P9WKZ5; L0TFI3; P65071; Q50722;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized protein Rv3403c;
GN   OrderedLocusNames=Rv3403c; ORFNames=MTCY78.25;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP46225.1; -; Genomic_DNA.
DR   PIR; H70735; H70735.
DR   RefSeq; NP_217920.1; NC_000962.3.
DR   RefSeq; WP_003417969.1; NZ_NVQJ01000027.1.
DR   AlphaFoldDB; P9WKZ5; -.
DR   STRING; 83332.Rv3403c; -.
DR   PaxDb; P9WKZ5; -.
DR   DNASU; 887907; -.
DR   GeneID; 45427399; -.
DR   GeneID; 887907; -.
DR   KEGG; mtu:Rv3403c; -.
DR   TubercuList; Rv3403c; -.
DR   eggNOG; COG4529; Bacteria.
DR   OMA; LTMIDQV; -.
DR   PhylomeDB; P9WKZ5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR038732; HpyO_NAD-binding.
DR   Pfam; PF13454; NAD_binding_9; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..533
FT                   /note="Uncharacterized protein Rv3403c"
FT                   /id="PRO_0000104123"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   533 AA;  57880 MW;  FD575D42C8082B84 CRC64;
     MLAFPYLMTM ITPPTFDVAF IGSGAACSMT LLEMADALLS SPSASPKLRI AVVERDEQFW
     CGIPYGQRSS IGSLAIQKLD DFADEPEKAA YRIWLEQNKQ RWLAFFQAEG GAAAARWICD
     NRDALDGNQW GELYLPRFLF GVFLSEQMIA AIAALGERDL AEIVTIRAEA MSAHSADGHY
     RIGLRPSGNG PTAIAAGKVV VAIGSPPTKA ILASDSEPAF TYINDFYSPG GESNVARLRD
     SLDRVESWEK RNVLVVGSNA TSLEALYLMR HDARIRARVR SITVISRSGV LPYMICNQPP
     EFDFPRLRTL LCTEAIAAAD LMSAIRDDLA TAEERSLNLA DLYDAVAALF GQALHKMDLV
     QQEEFFCVHG MNFTKLVRRA GRDCRQASEE LAADGTLSLL AGEVLRVDAC ASGQPFATMT
     YRAAGAEHTH PVPFAAVVNC GGFEELDTCS SPFLVSAMQN GLCRPNRTNR GLLVNDDFEA
     SPGFCVIGPL VGGNFTPKIR FWHVESAPRV RSLAKSLAAS LLASLQPVAL APC