ID   Y3410_MYCTU             Reviewed;         375 AA.
AC   P9WKI5; L0TE22; P65170; Q50716;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Uncharacterized oxidoreductase Rv3410c;
DE            EC=1.-.-.-;
GN   Name=guaB3; OrderedLocusNames=Rv3410c; ORFNames=MTCY78.18;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   LACK OF IMP DEHYDROGENASE ACTIVITY, AND FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21081761; DOI=10.1099/mic.0.042549-0;
RA   Usha V., Gurcha S.S., Lovering A.L., Lloyd A.J., Papaemmanouil A.,
RA   Reynolds R.C., Besra G.S.;
RT   "Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active
RT   against Mycobacterium tuberculosis.";
RL   Microbiology 157:290-299(2011).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Has no inosine-5'-monophosphate dehydrogenase activity.
CC       {ECO:0000269|PubMed:21081761}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46232.1; -; Genomic_DNA.
DR   PIR; G70736; G70736.
DR   RefSeq; NP_217927.1; NC_000962.3.
DR   RefSeq; WP_003418005.1; NZ_NVQJ01000027.1.
DR   AlphaFoldDB; P9WKI5; -.
DR   SMR; P9WKI5; -.
DR   STRING; 83332.Rv3410c; -.
DR   PaxDb; P9WKI5; -.
DR   GeneID; 45427406; -.
DR   GeneID; 887510; -.
DR   KEGG; mtu:Rv3410c; -.
DR   TubercuList; Rv3410c; -.
DR   eggNOG; COG0516; Bacteria.
DR   OMA; AARRDYM; -.
DR   PhylomeDB; P9WKI5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006183; P:GTP biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR005992; IMP_DH-rel2.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   PANTHER; PTHR11911; PTHR11911; 1.
DR   PANTHER; PTHR11911:SF85; PTHR11911:SF85; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   TIGRFAMs; TIGR01304; IMP_DH_rel_2; 1.
PE   1: Evidence at protein level;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Uncharacterized oxidoreductase Rv3410c"
FT                   /id="PRO_0000093782"
SQ   SEQUENCE   375 AA;  38991 MW;  221116AC214D9741 CRC64;
     MVEIGMGRTA RRTYELSEIS IVPSRRTRSS KDVSTAWQLD AYRFEIPVVA HPTDALVSPE
     FAIELGRLGG LGVLNGEGLI GRHLDVEAKI AQLLEAAAAD PEPSTAIRLL QELHAAPLNP
     DLLGAAVARI REAGVTTAVR VSPQNAQWLT PVLVAAGIDL LVIQGTIVSA ERVASDGEPL
     NLKTFISELD IPVVAGGVLD HRTALHLMRT GAAGVIVGYG STQGVTTTDE VLGISVPMAT
     AIADAAAARR DYLDETGGRY VHVLADGDIH TSGELAKAIA CGADAVVLGT PLAESAEALG
     EGWFWPAAAA HPSLPRGALL QIAVGERPPL ARVLGGPSDD PFGGLNLVGG LRRSMAKAGY
     CDLKEFQKVG LTVGG