Y3427_DROME
ID Y3427_DROME Reviewed; 1372 AA.
AC Q0KIC3; B5RIU0; Q8SX99;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Uncharacterized protein CG43427;
GN ORFNames=CG43427;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF52104.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF52104.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAM11083.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND RNA EDITING OF POSITION 679.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAM11083.1};
RC TISSUE=Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP RNA EDITING OF POSITION 679.
RX PubMed=17018572; DOI=10.1261/rna.254306;
RA Stapleton M., Carlson J.W., Celniker S.E.;
RT "RNA editing in Drosophila melanogaster: new targets and functional
RT consequences.";
RL RNA 12:1922-1932(2006).
CC -!- RNA EDITING: Modified_positions=679 {ECO:0000269|PubMed:12537569,
CC ECO:0000269|PubMed:17018572}; Note=Partially edited. Target of Adar.
CC {ECO:0000269|PubMed:17018572};
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DR EMBL; AE014297; AAF52104.2; -; Genomic_DNA.
DR EMBL; AE014297; AAO41500.1; -; Genomic_DNA.
DR EMBL; AY094730; AAM11083.1; -; mRNA.
DR EMBL; BT044214; ACH92279.1; -; mRNA.
DR RefSeq; NP_730864.1; NM_169014.3.
DR RefSeq; NP_730865.1; NM_169015.3.
DR RefSeq; NP_788576.1; NM_176399.3.
DR AlphaFoldDB; Q0KIC3; -.
DR SMR; Q0KIC3; -.
DR BioGRID; 65802; 30.
DR IntAct; Q0KIC3; 1.
DR STRING; 7227.FBpp0301012; -.
DR PaxDb; Q0KIC3; -.
DR DNASU; 40583; -.
DR EnsemblMetazoa; FBtr0308849; FBpp0301004; FBgn0263346.
DR EnsemblMetazoa; FBtr0308850; FBpp0301005; FBgn0263346.
DR EnsemblMetazoa; FBtr0308851; FBpp0301006; FBgn0263346.
DR GeneID; 40583; -.
DR KEGG; dme:Dmel_CG43427; -.
DR UCSC; CG31531-RA; d. melanogaster.
DR CTD; 40583; -.
DR FlyBase; FBgn0263346; CG43427.
DR VEuPathDB; VectorBase:FBgn0263346; -.
DR eggNOG; KOG1704; Eukaryota.
DR HOGENOM; CLU_250422_0_0_1; -.
DR InParanoid; Q0KIC3; -.
DR BioGRID-ORCS; 40583; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 40583; -.
DR PRO; PR:Q0KIC3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0263346; Expressed in thoracico-abdominal ganglion (Drosophila) and 46 other tissues.
DR ExpressionAtlas; Q0KIC3; baseline and differential.
DR Genevisible; Q0KIC3; DM.
DR GO; GO:0005911; C:cell-cell junction; IDA:FlyBase.
DR GO; GO:0005915; C:zonula adherens; IDA:FlyBase.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:FlyBase.
DR GO; GO:0150105; P:protein localization to cell-cell junction; IMP:FlyBase.
DR InterPro; IPR031865; DUF4757.
DR Pfam; PF15949; DUF4757; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; RNA editing.
FT CHAIN 1..1372
FT /note="Uncharacterized protein CG43427"
FT /id="PRO_0000337155"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..143
FT /evidence="ECO:0000255"
FT COILED 409..438
FT /evidence="ECO:0000255"
FT COILED 539..580
FT /evidence="ECO:0000255"
FT COMPBIAS 16..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..894
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 679
FT /note="K -> E (in RNA edited version)"
FT /evidence="ECO:0000269|PubMed:17018572"
SQ SEQUENCE 1372 AA; 149300 MW; 726436F41803F4D7 CRC64;
MEATDQEVML EGREDLMSTS ATSSTNGGDT NGCGKKLSVT SPDPTPYVTK QRVTRPTPPA
PSKNPMQFVQ IKPCNLYQTA QEQLKKAEEV KKLKEVKKEE PEEWQNNLDN WKSSRRKRVE
HIIDRAVETK KLELEEHDRL RRKSKTFTEM MEERAERGGP RGRAKLASLA VYNEDETNDL
SDLGIGTSSA SGKSSLSGDY DNNSVMSDHA AELDKAIGAA SSVAAGVTAQ NVDEQLNHIN
RNGSNGNHGN GAAVGQTGPS NSSKSAGRQY ISSPGYDTSS SNAQASSPDL CEYTYEGAIQ
DYKQRVQRAS SNGNGNANGK LIGEHIAYPT RRGSKIEDRL SGFEVTSPSD TQEGVEKQKV
DVPKVDISKR KEIFEQAKAE VSNGGAPAAP KLVFRDGLTN GNSATTAPKS EVRRLSGDIS
SIRDRMQSLE QQRKAFSSSK SVDVPVPPLK QRLNSLQQSV AKEEQKKPPL VALIDARQLE
IMRGEEERMR QQQQKEKHSP SQTTLCAPKP APPALIIEEP PVADTNDDSG IQEDTADELQ
QQQQLNAAIA ALALEERQLE EAANAVNQIE AEFDELTDLH PSPLPPSPAL PAVQQSLQQP
TVAQVPAQAV NQAAAPPLRD MEFSVSCTNN FIEPAKISPC DVNVVAASAV SVSKSGPTPN
PTSTPNMVSS SPNCNLRRKP SNEMVHHRNL LKMFKETFQN DDDLKEVCEI VTSPGQFTQI
IDFSKRPSNP PIPIPTLLPT STPIPTQIPR PLGKPPMSPK AVRLASSPKG HINPLSSPTN
SGFSPPQFSI NGRVEIFNSR QLDKPPTPPA PPKKTVRSEH PLKEAVPSPE VVMCAPPMTI
VDPDELPKPN TVKALSNCFS QSDSKSLTSP IMSPKPLPSG RIPQITPPAS PKPPKRVQLD
EVDRSSGDYA PVVGQTKAIV HTPPSKINAR ANQTLDPLAP NDSLCLHTSS PSEIPSLKAC
SPNESSLFKL ASSRPTSPSV DVASCQKFLN REAPKDIQLA EEDRKRMDQF AVEEMPCDKI
DVTKSPQPNT GFQIVTEDLV KKCDGKNISE AVRDLDVPPS QEDIALCAGL LDCLAPAQEP
ICDSIDVRNG PVPATGFQDI SEEEVKKCEK HNKNYVITNR PSSPIGSVRA AHSKALMDTC
EQIIAEERKA SSQMMKTSLP ESVEKPSTPL PGRKSKIPIP KPCCISASGT DSISRAGYVP
TAPSHLSGSA QQPLIARTHV VETEIKVKEI SPPSIPKTPE QTQLHASPTK EKKAKNIFDF
LRRNFGHQEE PQHHSTLNET LEKKVVLTST KSGVDVVNAD EFVRVDNSKF YLASELEDVP
VPPPLPKTPA PVNIEIRKKI TTNEILEENT TEQALTQEIS DLLDDEIMKL EN
