ID   Y3427_MYCTU             Reviewed;         251 AA.
AC   Q50701; E0YJK6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Putative ATP-binding protein Rv3427c in insertion sequence;
GN   OrderedLocusNames=Rv3427c; ORFNames=MTCY78.02;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=G4B1.2;
RX   PubMed=20639330; DOI=10.1128/jb.00536-10;
RA   Domenech P., Kolly G.S., Leon-Solis L., Fallow A., Reed M.B.;
RT   "Massive gene duplication event among clinical isolates of the
RT   Mycobacterium tuberculosis W/Beijing family.";
RL   J. Bacteriol. 192:4562-4570(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the IS21/IS1162 putative ATP-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; HM053706; ADM62325.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP46249.1; -; Genomic_DNA.
DR   PIR; H70738; H70738.
DR   RefSeq; NP_217944.1; NC_000962.3.
DR   RefSeq; WP_003418125.1; NZ_NVQJ01000027.1.
DR   AlphaFoldDB; Q50701; -.
DR   SMR; Q50701; -.
DR   STRING; 83332.Rv3427c; -.
DR   PaxDb; Q50701; -.
DR   DNASU; 887631; -.
DR   GeneID; 887631; -.
DR   KEGG; mtu:Rv3427c; -.
DR   TubercuList; Rv3427c; -.
DR   eggNOG; COG1484; Bacteria.
DR   InParanoid; Q50701; -.
DR   OMA; NGNSYRM; -.
DR   PhylomeDB; Q50701; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IBA:GO_Central.
DR   GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR028350; DNAC/ATP-binding.
DR   InterPro; IPR002611; IstB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01695; IstB_IS21; 1.
DR   PIRSF; PIRSF003073; DNAC_TnpB_IstB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Transposable element.
FT   CHAIN           1..251
FT                   /note="Putative ATP-binding protein Rv3427c in insertion
FT                   sequence"
FT                   /id="PRO_0000075481"
FT   BINDING         108..115
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   251 AA;  28028 MW;  8C97AE9202A7B894 CRC64;
     MSICDPALRN ALRTLKLSGM LDTLDARLAQ TRNGDLGHLE FLQALREDEI ARRESAALTR
     RLRRAKFEAQ ATFEDFDFTA NPKLPGAMLR DLAALRWLDA GESVILHGPV GVGKTHVAQA
     LVHAVARRGG DVRFAKTSRM LSDLAGGHAD RSWGQRIREY TKPLVLILDD FAMREHTAMH
     ADDLYELISD RAITGKPLIL TSNRAPNNWY GLFPNPVVAE SLLDRLINTS HQILMDGPSY
     RPRKRPGRTT S