ID   Y3428_MYCTU             Reviewed;         410 AA.
AC   Q50700; E0YJL0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Putative transposase Rv3428c;
GN   OrderedLocusNames=Rv3428c; ORFNames=MTCY78.01;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=G4B1.2;
RX   PubMed=20639330; DOI=10.1128/jb.00536-10;
RA   Domenech P., Kolly G.S., Leon-Solis L., Fallow A., Reed M.B.;
RT   "Massive gene duplication event among clinical isolates of the
RT   Mycobacterium tuberculosis W/Beijing family.";
RL   J. Bacteriol. 192:4562-4570(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SIMILARITY: Belongs to the transposase IS21/IS408/IS1162 family.
CC       {ECO:0000305}.
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DR   EMBL; HM053707; ADM62329.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP46250.1; -; Genomic_DNA.
DR   PIR; A70739; A70739.
DR   RefSeq; NP_217945.1; NC_000962.3.
DR   RefSeq; WP_003917171.1; NC_000962.3.
DR   AlphaFoldDB; Q50700; -.
DR   STRING; 83332.Rv3428c; -.
DR   PaxDb; Q50700; -.
DR   DNASU; 887621; -.
DR   GeneID; 887621; -.
DR   KEGG; mtu:Rv3428c; -.
DR   TubercuList; Rv3428c; -.
DR   eggNOG; COG4584; Bacteria.
DR   InParanoid; Q50700; -.
DR   OMA; MRQTHIA; -.
DR   PhylomeDB; Q50700; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transposable element.
FT   CHAIN           1..410
FT                   /note="Putative transposase Rv3428c"
FT                   /id="PRO_0000075471"
FT   DOMAIN          40..220
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT   REGION          390..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   410 AA;  45494 MW;  50F8F62A9FBE2354 CRC64;
     MATIAQRLRD DHGVAASESS VRRWIATHFA EEVARERVTV PRGPVDAGSE AQIDYGRLGM
     WFDPATARRV AVWAFVMVLA FSRHLFVRPV IRMDQTAWCA CHVAAFEFFD GVPARLVCDN
     LRTGVDKPDL YDPQINRSYA ELASHYATLV DPARARKPKD KPRVERPMTY VRDSFWKGRE
     FDSLAQMQQA AVTWSTEVAG LRYLRALEGA QPLRMFEAVE QQALIALPPR AFELTSWSIG
     TVGVDTHLKV GKALYSVPWR LIGQRLHART AGDVVQIFAG NDVVATHVRR PSGRSTDFSH
     YPPEKIAFHM RTPTWCRHTA ELVGPASQQV IAEFMRDNAI HHLRSAQGVL GLRDKHGCDR
     LEAACARAIE VGDPSYRTIK GILVAGTEHA ANEPTTSSPA STAGGVPARP