Y3435_DICDI
ID Y3435_DICDI Reviewed; 409 AA.
AC Q557K2; Q86KI2;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0273435/DDB_G0273505;
GN ORFNames=DDB_G0273435;
GN and
GN ORFNames=DDB_G0273505;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70672.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70707.1; -; Genomic_DNA.
DR RefSeq; XP_644617.1; XM_639525.1.
DR RefSeq; XP_644633.1; XM_639541.1.
DR AlphaFoldDB; Q557K2; -.
DR SMR; Q557K2; -.
DR STRING; 44689.DDB0168209; -.
DR PaxDb; Q557K2; -.
DR EnsemblProtists; EAL70672; EAL70672; DDB_G0273435.
DR EnsemblProtists; EAL70707; EAL70707; DDB_G0273505.
DR GeneID; 8618981; -.
DR GeneID; 8618996; -.
DR KEGG; ddi:DDB_G0273435; -.
DR KEGG; ddi:DDB_G0273505; -.
DR dictyBase; DDB_G0273435; -.
DR dictyBase; DDB_G0273505; -.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_040980_0_0_1; -.
DR InParanoid; Q557K2; -.
DR OMA; PTKEFSL; -.
DR PhylomeDB; Q557K2; -.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q557K2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; PTHR10131; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..409
FT /note="TNF receptor-associated factor family protein
FT DDB_G0273435/DDB_G0273505"
FT /id="PRO_0000393754"
FT DOMAIN 252..380
FT /note="MATH"
FT ZN_FING 20..59
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 75..145
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 145..201
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT COILED 221..250
FT /evidence="ECO:0000255"
SQ SEQUENCE 409 AA; 47489 MW; 7CC0B97411C8A5EB CRC64;
MKYSIDDLIF SKDIDEDLYC QLCCNLMNES VSCPNGHCLC KGCFHKQIET VKSECPICCI
PVTIQTLCKN IYLQKHINNL KVYCPNSFLN NDNNKLILDE KKGCKEILTI EQLKNGKHLK
ECKFTFVSCE YNEKCGKYRM NEIENHQDQC NYYPTKCFYC KNDFERMNLS NHLLLDCPLV
IIGCRYKDGG CNETFPRHEL SKHLALEDNH QQYISNIING HQSLLKSTSK QLKQLRSSCE
ELETKLINND YSFNGRWIIK QFSAHFDLFK ENPFTNLIIS PPIFLTPTKE FSLSLSADTV
VNSVNCISVI LSKQFQSSST IKFSFEITNQ SQTKSIKKEE KKKFSHLIGS SHSIEFPTSE
IYNIHNKFIV NDQLIIKFNI KILSIQDEQQ EIEESEENFN NTLITELEE
