ID   Y3435_MYCPA             Reviewed;         335 AA.
AC   Q73UD3;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=UPF0353 protein MAP_3435c {ECO:0000255|HAMAP-Rule:MF_01340};
GN   OrderedLocusNames=MAP_3435c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01340};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01340}.
CC   -!- SIMILARITY: Belongs to the UPF0353 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01340}.
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DR   EMBL; AE016958; AAS05985.1; -; Genomic_DNA.
DR   RefSeq; WP_003874486.1; NC_002944.2.
DR   AlphaFoldDB; Q73UD3; -.
DR   SMR; Q73UD3; -.
DR   STRING; 262316.MAP_3435c; -.
DR   EnsemblBacteria; AAS05985; AAS05985; MAP_3435c.
DR   KEGG; mpa:MAP_3435c; -.
DR   PATRIC; fig|262316.17.peg.3651; -.
DR   eggNOG; COG2304; Bacteria.
DR   HOGENOM; CLU_024570_2_0_11; -.
DR   OMA; WWFGRVM; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   HAMAP; MF_01340; UPF0353; 1.
DR   InterPro; IPR024163; Aerotolerance_reg_N.
DR   InterPro; IPR022933; UPF0353.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF07584; BatA; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="UPF0353 protein MAP_3435c"
FT                   /id="PRO_0000057647"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   DOMAIN          98..294
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
SQ   SEQUENCE   335 AA;  35316 MW;  87D9080F9EF0D9A2 CRC64;
     MKLPLLGPVS VTGFQNPWFF LALLAVLLVI GLYVVQQFAR RRRVLRFANM EVLERVAPPH
     PSRWRHVPTI LLATSLVLLT TAMAGPTSDV RIPLNRAVVM LVIDVSESMA STDVPPNRLA
     AAKEAGKQFA DQLTPAINLG LVEFAANATL LVPPTTNRAA VKAGIDSLQP APKTATGEGI
     FTALQAIATV GSVMGGGEGP PPARIVLESD GAENVPLDPN APQGAFTAAR AAKAEGVQIS
     TISFGTPYGT VDYEGATIPV PVDDQTLQKI CEITDGQAFH ADSLDSLKNV YSTLQRQIGY
     ETVKGDASMA WMLLGAVVLA GAVLAGLLLN RRLPA