ID   Y3443_DICDI             Reviewed;         393 AA.
AC   Q54R14;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=SET domain-containing protein DDB_G0283443;
DE            EC=2.1.1.-;
GN   ORFNames=DDB_G0283443;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AAFI02000055; EAL65706.1; -; Genomic_DNA.
DR   RefSeq; XP_639077.1; XM_633985.1.
DR   AlphaFoldDB; Q54R14; -.
DR   SMR; Q54R14; -.
DR   STRING; 44689.DDB0220713; -.
DR   PaxDb; Q54R14; -.
DR   PRIDE; Q54R14; -.
DR   EnsemblProtists; EAL65706; EAL65706; DDB_G0283443.
DR   GeneID; 8624102; -.
DR   KEGG; ddi:DDB_G0283443; -.
DR   dictyBase; DDB_G0283443; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_702894_0_0_1; -.
DR   InParanoid; Q54R14; -.
DR   OMA; CACTICA; -.
DR   PhylomeDB; Q54R14; -.
DR   Reactome; R-DDI-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:Q54R14; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..393
FT                   /note="SET domain-containing protein DDB_G0283443"
FT                   /id="PRO_0000389439"
FT   DOMAIN          17..312
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ   SEQUENCE   393 AA;  46230 MW;  E00A6AAC05945923 CRC64;
     MENNNNNNKN DNEINFKKIE INETLESGKF IESKIDMKLG ELIIKVQSPM CFSFHKHLVN
     QFCFNCFSNS HEINNAKFNK FKVDINKNYI IRCNNCKLIY FCSDECFEKV MSIESFQDST
     STNIHTPLEC LILSNYHDQT ISPKINTLHD QTENRMIINY LSKIAYSTNN NNKFKLLLIE
     MNQLIGDFNN DNNNQTLSLN EIKNIKNKSF NLRKLFNNFF FNIDKVIIEE LYAKSQRNSF
     GLWKNSDECF GLSMYGNQTI YNNNNDKDDN ISISYFNHSC FPNCVRVQEN QSISIYSLIP
     IKKGDELSIS YIDIRMSKND RLLHLKEIYY FECKCKRCTL PPLSNLSLEI EKTIENYTCK
     NQSIKCTGIL YLPPFNKIQR ICNFCHWKEP INN