Y3449_DICDI
ID Y3449_DICDI Reviewed; 332 AA.
AC Q557G4;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Uncharacterized protein DDB_G0273449/DDB_G0273577;
DE Flags: Precursor;
GN ORFNames=DDB_G0273449;
GN and
GN ORFNames=DDB_G0273577;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX PubMed=12963116; DOI=10.1016/s0925-4773(03)00136-9;
RA Muramoto T., Suzuki K., Shimizu H., Kohara Y., Kohriki E., Obara S.,
RA Tanaka Y., Urushihara H.;
RT "Construction of a gamete-enriched gene pool and RNAi-mediated functional
RT analysis in Dictyostelium discoideum.";
RL Mech. Dev. 120:965-975(2003).
RN [4]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS], AND DISRUPTION PHENOTYPE.
RX PubMed=15817229; DOI=10.1016/j.mod.2004.11.015;
RA Muramoto T., Takeda S., Furuya Y., Urushihara H.;
RT "Reverse genetic analyses of gamete-enriched genes revealed a novel
RT regulator of the cAMP signaling pathway in Dictyostelium discoideum.";
RL Mech. Dev. 122:733-743(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Highly enriched in gametes.
CC {ECO:0000269|PubMed:12963116, ECO:0000269|PubMed:15817229}.
CC -!- DISRUPTION PHENOTYPE: No effect on growth rate, asexual development,
CC sexual cell fusion, or zygote formation. {ECO:0000269|PubMed:15817229}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70679.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70743.1; -; Genomic_DNA.
DR RefSeq; XP_644580.1; XM_639488.1.
DR RefSeq; XP_644671.1; XM_639579.1.
DR AlphaFoldDB; Q557G4; -.
DR PaxDb; Q557G4; -.
DR PRIDE; Q557G4; -.
DR EnsemblProtists; EAL70679; EAL70679; DDB_G0273449.
DR EnsemblProtists; EAL70743; EAL70743; DDB_G0273577.
DR GeneID; 8618945; -.
DR GeneID; 8619032; -.
DR KEGG; ddi:DDB_G0273449; -.
DR KEGG; ddi:DDB_G0273577; -.
DR dictyBase; DDB_G0273449; -.
DR dictyBase; DDB_G0273577; -.
DR eggNOG; ENOG502R1D1; Eukaryota.
DR HOGENOM; CLU_837895_0_0_1; -.
DR InParanoid; Q557G4; -.
DR OMA; YDWSFIR; -.
DR PhylomeDB; Q557G4; -.
DR PRO; PR:Q557G4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0017183; P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine; IBA:GO_Central.
DR GO; GO:0019953; P:sexual reproduction; IEP:dictyBase.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IBA:GO_Central.
DR InterPro; IPR044248; DPH3/4-like.
DR PANTHER; PTHR21454; PTHR21454; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..332
FT /note="Uncharacterized protein DDB_G0273449/DDB_G0273577"
FT /id="PRO_0000392619"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 332 AA; 37705 MW; 4592DAD69E7BE347 CRC64;
MKFIYSIFII IQIIFFINLI NGQIVRGPDL QLGYVENGTM LLGSPNVVNI GDQNFMNTKD
LSNSSWTDHR YNRYDWSFIR FHIRNNQSGF EATADFHPRV DEFSTIKFSA NGLIQYLNET
NKNRNVFKNR EVEGYTVWAE IPYSKNVTSF TSRLVDVPCQ ETLTNGSVVV STDKACQNVT
DITTATYQKV ENYNSTVLEP IILPPKHIFE FSTRTFVSYF TIIFQLDNGA IVDAVWDGDR
DTSICKNCDS CIDNQCATKF DDMRCDEGVG CQLKFFLAWA GVDKSGKNCV SLNKIPSKFQ
KYSATAIKNM GTGLVSDFFY KINDNNNNPN TA
