ID   Y344_CHLMU              Reviewed;         619 AA.
AC   Q9PKW7;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Putative zinc metalloprotease TC_0344;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=TC_0344;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AE002160; AAF39205.1; -; Genomic_DNA.
DR   PIR; H81712; H81712.
DR   RefSeq; WP_010230221.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PKW7; -.
DR   STRING; 243161.TC_0344; -.
DR   EnsemblBacteria; AAF39205; AAF39205; TC_0344.
DR   GeneID; 1246387; -.
DR   KEGG; cmu:TC_0344; -.
DR   eggNOG; COG0750; Bacteria.
DR   HOGENOM; CLU_025778_0_0_0; -.
DR   OMA; YSRIVGW; -.
DR   OrthoDB; 1395197at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 2.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Membrane; Metal-binding;
KW   Metalloprotease; Protease; Transmembrane; Transmembrane helix; Zinc.
FT   CHAIN           1..619
FT                   /note="Putative zinc metalloprotease TC_0344"
FT                   /id="PRO_0000088435"
FT   TRANSMEM        103..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        593..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         20
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         24
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   619 AA;  69100 MW;  14E8236004779AFF CRC64;
     MTVIYFVLAA LALGFLILIH ELGHLLAAKA VGMTVESFSI GFGPALVRKK MGSIEYRIGA
     IPFGGYVRIK GMDRNDKEIS EDREKTVYDI PGGFFSKSPW KRIFVLAAGP LANILVALFA
     FGILYFSGGR TKPFSEHTSI VGWAHPSLEQ KGLRPGDRIF LCNGQVYSGN KMAFSSSLLD
     RKLSLQGEHP AYFSEAESFS LDVPFNPSLE GVPCLGASYL LYRGSEPLPE KSPLIDAGLS
     EGDRLVWMDG ALVFSGVQVS QILNEKKAFL RIERQGKIVF VRQSRVLAGD LQLTSYFKNE
     LIDCQYEAGL KGKWASLYML PYIINSDGFV ESKINLLNTD QQSLDYHLEL GDRIVAVDGI
     PVMSNADILR LVQDHRVSLI FQRMSSGQLS VLDQKAADKA FIDSYDMDDL LRVAGSVGEE
     REVSHLGEYR LVTRVQPKPW VHIYSEELLD KQRALASKFR DEQEKRYYLE RIESEKQRIS
     LGIPLKDLAV QYNPAPLVLM GESISDSLRT VKALGSGRLS PQWLSGPVGI VRILHTGWSM
     GIPEALSWIG LISINLAVLN LLPIPVLDGG YILLCLWESV SRRRLNMRLI EKGLVPFMIL
     LILFFVFLTL QDLSRVFIG