Y344_CHLPN
ID Y344_CHLPN Reviewed; 621 AA.
AC Q9K275; Q9JSG0; Q9Z8J9;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Putative zinc metalloprotease CPn_0344/CP_0416/CPj0344/CpB0350;
DE EC=3.4.24.-;
GN OrderedLocusNames=CPn_0344, CP_0416, CPj0344, CpB0350;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR EMBL; AE001363; AAD18488.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38260.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98552.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98282.1; -; Genomic_DNA.
DR PIR; A72091; A72091.
DR PIR; D81578; D81578.
DR PIR; F86533; F86533.
DR RefSeq; NP_224544.1; NC_000922.1.
DR RefSeq; WP_010892060.1; NZ_LN846995.1.
DR AlphaFoldDB; Q9K275; -.
DR STRING; 115711.CP_0416; -.
DR PRIDE; Q9K275; -.
DR EnsemblBacteria; AAD18488; AAD18488; CPn_0344.
DR EnsemblBacteria; AAF38260; AAF38260; CP_0416.
DR GeneID; 45050389; -.
DR KEGG; cpa:CP_0416; -.
DR KEGG; cpj:yaeL; -.
DR KEGG; cpn:CPn_0344; -.
DR KEGG; cpt:CpB0350; -.
DR PATRIC; fig|115713.3.peg.380; -.
DR eggNOG; COG0750; Bacteria.
DR HOGENOM; CLU_025778_0_0_0; -.
DR OMA; YSRIVGW; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR004387; Pept_M50_Zn.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR42837; PTHR42837; 2.
DR Pfam; PF02163; Peptidase_M50; 1.
DR SUPFAM; SSF50156; SSF50156; 2.
DR PROSITE; PS00142; ZINC_PROTEASE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Hydrolase; Membrane; Metal-binding;
KW Metalloprotease; Protease; Transmembrane; Transmembrane helix; Zinc.
FT CHAIN 1..621
FT /note="Putative zinc metalloprotease
FT CPn_0344/CP_0416/CPj0344/CpB0350"
FT /id="PRO_0000088436"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..583
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..613
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 21
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT BINDING 20
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT BINDING 24
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT CONFLICT 224
FT /note="G -> S (in Ref. 1; AAD18488)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="T -> K (in Ref. 1; AAD18488)"
FT /evidence="ECO:0000305"
FT CONFLICT 598
FT /note="V -> D (in Ref. 3; BAA98552)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 621 AA; 69821 MW; 30B09776FEA271BF CRC64;
MTIIYFILAA LALGILVLIH ELGHLVVAKA VGMAVESFSI GFGPALFKKR IGGIEYRIGC
IPFGGYVRIR GMERTKEKGE KGKIDSVYDI PQGFFSKSPW KRILVLVAGP LANILLAVLA
FSILYMNGGR SKNYSDCSKV VGWVHPVLQA EGLLPGDEIL TCNGKPYVGD KDMLTTSLLE
GHLNLEIKRP GYLTVPSKEF AIDVEFDPTK FGVPCSGASY LLYGNQVPLT KNSPMENSEL
RPNDRFVWMD GTLLFSMAQI SQILNESYAF VKVARNDKIF FSRQPRVLAS VLHYTPYLRN
ELIDTQYEAG LKGKWSSLYT LPYVINSYGY IEGELTAIDP ESPLPQPQER LQLGDRILAI
DGTPVSGSVD ILRLVQNHRV SIIVQQMSPQ ELEEVNSRDA DKRFIASYHS EDLLQILNHL
GESHPVEVAG PYRLLDPVQP RPWIDVYSSE SLDKQLEVAK KIKNKDKQRY YLERLDAEKQ
KPSLGISLKD LKVRYNPSPV VMLSNITKES LITLKALVTG HLSPQWLSGP VGIVQVLHTG
WSVGFSEVLF WIGLISMNLA VLNLLPIPVL DGGYILLCLW EIVTRRRLNM KIVERILVPF
TFLLIIFFIF LTFQDLFRFF G
