ID   Y3469_MYCBP             Reviewed;         348 AA.
AC   A1KP90;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 3.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase BCG_3469;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=BCG_3469;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250|UniProtKB:Q9CCZ4}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AM408590; CAL73458.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1KP90; -.
DR   SMR; A1KP90; -.
DR   PRIDE; A1KP90; -.
DR   KEGG; mbb:BCG_3469; -.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; PFADDHI; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..348
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase BCG_3469"
FT                   /id="PRO_0000361146"
FT   BINDING         171
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CCZ4"
FT   BINDING         200..201
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CCZ4"
SQ   SEQUENCE   348 AA;  38198 MW;  8C06DE947EFEBFBD CRC64;
     MARPMGKLPS NTRKCAQCAM AEALLEIAGQ TINQKDLGRS GRMTRTDNDT WDLASSVGAT
     ATMIATARAL ASRAENPLIN DPFAEPLVRA VGIDLFTRLA SGELRLEDIG DHATGGRWMI
     DNIAIRTKFY DDFFGDATTA GIRQVVILAA GLDTRAYRLP WPPGTVVYEI DQPAVIKFKT
     RALANLNAEP NAERHAVAVD LRNDWPTALK NAGFDPARPT AFSAEGLLSY LPPQGQDRLL
     DAITALSAPD SRLATQSPLV LDLAEEDEKK MRMKSAAEAW RERGFDLDLT ELIYFDQRND
     VADYLAGSGW QVTTSTGKEL FAAQGLPPFE DDHITRFADR RYISAVLK