ID   Y3479_MYCTU             Reviewed;        1082 AA.
AC   O06342;
DT   01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-2015, sequence version 4.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Uncharacterized membrane protein Rv3479;
GN   OrderedLocusNames=Rv3479 {ECO:0000312|EMBL:CCP46301.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP46301.1; Type=Erroneous initiation; Note=Truncated N-terminus.;
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DR   EMBL; AL123456; CCP46301.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_217996.2; NC_000962.3.
DR   AlphaFoldDB; O06342; -.
DR   STRING; 83332.Rv3479; -.
DR   PaxDb; O06342; -.
DR   PRIDE; O06342; -.
DR   DNASU; 888478; -.
DR   GeneID; 888478; -.
DR   KEGG; mtu:Rv3479; -.
DR   PATRIC; fig|83332.12.peg.3885; -.
DR   TubercuList; Rv3479; -.
DR   eggNOG; COG1752; Bacteria.
DR   InParanoid; O06342; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR024282; DUF3376.
DR   InterPro; IPR019894; Patatin-related_protein.
DR   InterPro; IPR002641; PNPLA_dom.
DR   Pfam; PF11856; DUF3376; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   TIGRFAMs; TIGR03607; TIGR03607; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1082
FT                   /note="Uncharacterized membrane protein Rv3479"
FT                   /id="PRO_0000432522"
FT   TRANSMEM        959..979
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        982..1002
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1012..1032
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1057..1077
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          50..319
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           120..124
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           306..308
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        122
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        306
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ   SEQUENCE   1082 AA;  115605 MW;  96EBB31106D2AFA2 CRC64;
     MFPAAVGVLW QSGLRDPTPP GGPHGIEGLS LAFEKPSPVT ALTQELRFAT TMTGGVSLAI
     WMAGVTREIN LLAQASQWRR LGGTFPTNSQ LTNESAASLR LYAQLIDLLD MVVDVDILSG
     TSAGGINAAL LASSRVTGSD LGGIRDLWLD LGALTELLRD PRDKKTPSLL YGDERIFAAL
     AKRLPKLATG PFPPTTFPEA ARTPSTTLYI TTTLLAGETS RFTDSFGTLV QDVDLRGLFT
     FTETDLARPD TAPALALAAR SSASFPLAFE PSFLPFTKGT AKKGEVPARP AMAPFTSLTR
     PHWVSDGGLL DNRPIGVLFK RIFDRPARRP VRRVLLFVVP SSGPAPDPMH EPPPDNVDEP
     LGLIDGLLKG LAAVTTQSIA ADLRAIRAHQ DCMEARTDAK LRLAELAATL RNGTRLLTPS
     LLTDYRTREA TKQAQTLTSA LLRRLSTCPP ESGPATESLP KSWSAELTVG GDADKVCRQQ
     ITATILLSWS QPTAQPLPQS PAELARFGQP AYDLAKGCAL TVIRAAFQLA RSDADIAALA
     EVTEAIHRAW RPTASSDLSV LVRTMCSRPA IRQGSLENAA DQLAADYLQQ STVPGDAWER
     LGAALVNAYP TLTQLAASAS ADSGAPTDSL LARDHVAAGQ LETYLSYLGT YPGRADDSRD
     APTMAWKLFD LATTQRAMLP ADAEIEQGLE LVQVSADTRS LLAPDWQTAQ QKLTGMRLHH
     FGAFYKRSWR ANDWMWGRLD GAGWLVHVLL DPRRVRWIVG ERADTNGPQS GAQWFLGKLK
     ELGAPDFPSP GYPLPAVGGG PAQHLTEDML LDELGFLDDP AKPLPASIPW TALWLSQAWQ
     QRVLEEELDG LANTVLDPQP GKLPDWSPTS SRTWATKVLA AHPGDAKYAL LNENPIAGET
     FASDKGSPLM AHTVAKAAAT AAGAAGSVRQ LPSVLKPPLI TLRTLTLSGY RVVSLTKGIA
     RSTIIAGALL LVLGVAAAIQ SVTVFGVTGL IAAGTGGLLV VLGTWQVSGR LLFALLSFSV
     VGAVLALATP VVREWLFGTQ QQPGWVGTHA YWLGAQWWHP LVVVGLIALV AIMIAAATPG
     RR