ID   Y347_HELPJ              Reviewed;         293 AA.
AC   Q9ZMA1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase jhp_0321;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=jhp_0321;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001439; AAD05911.1; -; Genomic_DNA.
DR   PIR; A71946; A71946.
DR   RefSeq; WP_001117208.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMA1; -.
DR   SMR; Q9ZMA1; -.
DR   STRING; 85963.jhp_0321; -.
DR   EnsemblBacteria; AAD05911; AAD05911; jhp_0321.
DR   KEGG; hpj:jhp_0321; -.
DR   PATRIC; fig|85963.30.peg.692; -.
DR   eggNOG; COG0564; Bacteria.
DR   OMA; FMQKKVK; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..293
FT                   /note="Uncharacterized RNA pseudouridine synthase jhp_0321"
FT                   /id="PRO_0000162734"
FT   ACT_SITE        119
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   293 AA;  33668 MW;  D7EF3EC54A8E6168 CRC64;
     MPFVEEEFEI LKPTKALFLV RDVLKCSLKE AQRHLDKQRL KQNQQTVRKS QIIQGVVRLI
     YFKPNEKQEK LVFEAKDFGV FDKPAQIYTH PKGYFYHESL LDCIQSHFGK NAHPAHRLDY
     ETSGLVLAGK TLQSTKDLKA LFMQKKVKKT YLALAHGLVD KSIIINKPIL TPQNIQKDLR
     IRSQISPLGK PSITLVEPLS YNPFLDISLL KITPLTGRTH QIRLHLSSVD HRIVGEGLYG
     VADENAREYL QLKRENNAPT LMLHAASLEF EFKGAHYKIA SPMPERFMPF LKD