Y347_HELPY
ID Y347_HELPY Reviewed; 298 AA.
AC O25114;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase HP_0347;
DE EC=5.4.99.-;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=HP_0347;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC -!- INTERACTION:
CC O25114; P94844: dapB; NbExp=3; IntAct=EBI-7497815, EBI-7497752;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; AE000511; AAD07404.1; -; Genomic_DNA.
DR PIR; C64563; C64563.
DR RefSeq; NP_207145.1; NC_000915.1.
DR RefSeq; WP_001117124.1; NC_018939.1.
DR AlphaFoldDB; O25114; -.
DR SMR; O25114; -.
DR DIP; DIP-3403N; -.
DR IntAct; O25114; 10.
DR MINT; O25114; -.
DR STRING; 85962.C694_01760; -.
DR PaxDb; O25114; -.
DR EnsemblBacteria; AAD07404; AAD07404; HP_0347.
DR KEGG; hpy:HP_0347; -.
DR PATRIC; fig|85962.47.peg.370; -.
DR eggNOG; COG0564; Bacteria.
DR OMA; FMQKKVK; -.
DR PhylomeDB; O25114; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 1: Evidence at protein level;
KW Isomerase; Reference proteome.
FT CHAIN 1..298
FT /note="Uncharacterized RNA pseudouridine synthase HP_0347"
FT /id="PRO_0000162733"
FT ACT_SITE 119
FT /evidence="ECO:0000250"
SQ SEQUENCE 298 AA; 34347 MW; 116E4DD87779B15C CRC64;
MPFVEEEFEI LKPTKALFFV RDVLKCSLKE AQRHLDKQRL KQNQQAVRKS QIIQGVVRLI
HFKPNEKTQA LVFETKDFGV FDKPHQVYTH PKGYFYHESL LDCIQSHFGK NAHPAHRLDY
ETSGLVLAGK TLQSVKDLKA LFMQKKVKKT YLALAHGLVE KSMKIDKPIL TPQNIQKDLH
IRSKISPLGK QSITLVEPLS YNPFLDISLL KITPLTGRTH QIRLHLSSVD HRIVGEGLYG
VADENAREYL QLKRENNAPL LMLHAASLEF EFKGAIYKIA SPMPERFMPF LKDLSFFY
