Y3509_DICDI
ID Y3509_DICDI Reviewed; 450 AA.
AC Q557K0; Q86KI3;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0273433/DDB_G0273509;
GN ORFNames=DDB_G0273433;
GN and
GN ORFNames=DDB_G0273509;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70671.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70709.1; -; Genomic_DNA.
DR RefSeq; XP_644615.1; XM_639523.1.
DR RefSeq; XP_644635.1; XM_639543.1.
DR AlphaFoldDB; Q557K0; -.
DR SMR; Q557K0; -.
DR STRING; 44689.DDB0168208; -.
DR PaxDb; Q557K0; -.
DR EnsemblProtists; EAL70671; EAL70671; DDB_G0273433.
DR EnsemblProtists; EAL70709; EAL70709; DDB_G0273509.
DR GeneID; 8618979; -.
DR GeneID; 8618998; -.
DR KEGG; ddi:DDB_G0273433; -.
DR KEGG; ddi:DDB_G0273509; -.
DR dictyBase; DDB_G0273433; trafK-1.
DR dictyBase; DDB_G0273509; trafK-2.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_040980_0_0_1; -.
DR InParanoid; Q557K0; -.
DR OMA; HISCHEC; -.
DR PhylomeDB; Q557K0; -.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q557K0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.40.10; -; 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; PTHR10131; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..450
FT /note="TNF receptor-associated factor family protein
FT DDB_G0273433/DDB_G0273509"
FT /id="PRO_0000393757"
FT DOMAIN 319..439
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT ZN_FING 26..73
FT /note="RING-type; degenerate"
FT ZN_FING 129..185
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 186..243
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT COILED 257..297
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 52186 MW; C097E25AC57FCB6C CRC64;
MDKKINLDYL IDDIIVNSDD LTPFQCQICF NSVIDFKKET LSFDVLQCRN GHISCHECWN
RQLSIKQECP SCKVKTLPSE LSRNIFLENA FRALKVICPN KFKESKFQGE AVHCENGCPE
ILKVELLEHH LKECQYQFIK CPNNSNKCKY IIRKNQIEHH NQSVCDYSLI QCEKCSELIE
RKKLNKHIES ECDTLMITCS KCSASIGKKL MNHHLETDCP MEEISCLYKA GGCNKRFLRS
QLSQHLSENN NHIFYIQNVM DLHKLQLDEC NQDYRKLEKQ NRDLEKRLFY LESTVNSTVI
NSKPHECGGG GGGGSGNNVY KGKWVINNWD RKLREYPISK SLNSPFFQIG SSKFFIMLYP
NGNNEVKGFL SIFLYKIYDR PSLVKYSLEA KNIDPTKNYK NTHTNNFINN NGNGWFKWIE
NKSQNGFFSN NSLTISISIK IIQDHSLVTE
